Genomics has revolutionised medicine, providing information on a scale not previously available. Pathogen Genomics is part of this revolution and the applications of this technology have provided crucial information on pathogen discovery, new drug development, outbreak control and antibiotic resistance. This unit of study will introduce students to bacterial genomes, how they change and how that change can be measured. Students will learn how DNA is sequenced in the laboratory and develop analytical skills in bacterial genomics, using public databases and the University of Sydney's high-performance computing cluster. Students will experience the breadth and power of pathogen genomics and its wide applications within diagnostics and research. A combination of lectures and practicals will impart knowledge and understanding of a large number of applications used in genomics today. Case studies will enable students to perform genomic analysis on unknown samples and apply the technological knowledge gained from the unit to answer biological questions. This unit will provide students with a greater appreciation for the artistry of bacterial virulence and how understanding these mechanisms can inform overall general health outcomes for humans.
2x1hr lec/wk and 5x1hr seminars or 6x3hr practical classes/sem
1x 1.5hr examination (50%), group project (20%) and presentation (10%) and 1x1000 wd paper review (20%)
Online readings will be provided
Basic understanding of microbiology or medical microbiology and genetics.