This unit of study aims to provide the background to the study of drugs and the important interactions of drugs and their targets. Learning about the molecular bases of such interactions requires consideration of the fundamental processes as replication, transcription and translation involving the macromolecules of life: proteins, DNA and RNA. The course also covers fundamental protein actions and mechanisms of the regulation of such targets, and proteomics, as well as fundamental molecular interactions important for understanding the action of, the detection of, and also diagnostic approaches applied to drugs and metabolites. Fuel metabolism and storage is considered, including metabolic adaptation and disorders of metabolism. Students get experience with a variety of practical techniques to assist learning in the course.
3x1hr lectures/week, 5x3hr labs/semester, 1x3hr workshop/semester
2.5hr exam (65%), laboratory assessments (25%), major quiz (10%)
Nelson, DL. and Cox, MM. Lehninger: Principles of Biochemistry (7e edition; electronic version), W.H. Freeman, 2017 Patrick, GL. An Introduction to Medicinal Chemistry (6th ed) Oxford University Press, 2017
(CHEM1611 or CHEM11X2 or CHEM19X2 or CHEM1904) and (CHEM1612 or CHEM11X1 or CHEM19X1 or CHEM1903) and PHAR1812 and (BIOL1XX7 or MBLG1XX1).