In this unit of study students learn to evaluate the physicochemical principles, design, formulation, and manufacture of pharmaceutical dose forms. The formulation of liquid dose forms including parenteral, nasal, ophthalmic and aural products is discussed. Related topics such as diffusion and dissolution of drugs, drug solubilisation, surface and interfacial tension, surface active materials, micelle formation, pharmaceutical complexes and drug-packaging interactions are covered. Other topics covered in this unit include biomaterials; solid dose forms and particle science that comprise tableting and capsule technology; rheology, freezing point depression, osmosis, dispersion dose forms including suspensions, colloidal dispersions, and emulsions; topical dose forms and semisolids; inhalation pharmaceutical aerosols; biopharmaceuticals including protein and peptide drugs, vaccines and their formulations; rectal products; novel drug delivery technologies. Aspects pertaining to the stability of dose forms are also presented in this unit.
3x1hr lectures/week, 1x1hr tutorial/week, 2x4hr tabletting practicals, 5x3hr physical chemistry practicals and 3x2.5hr compounding practicals
2hr final exam (55%), mid semester quiz (10%) and laboratory practicals (35%)
Aulton, M.E. (1988). Pharmaceutics: The Science of Dosage Form Design (7th ed). Churchill Livingston Florence, A.T., and Attwood, D. (2015). Physicochemical Principles of Pharmacy (6th ed). Pharmaceutical Press
6 credit points of Biochemistry, 12 credit points of Chemistry, 12 credit points of Pharmacology, 12 credit points of Physiology.