This unit of study is intended to provide an understanding of drug metabolism, pharmacokinetics, pharmacodynamics and pharmacogenetics, and the clinical application of these concepts to support the safe and effective use of medicines. Lecture topics will include metabolic enzymes and pathways, identification of metabolites, pharmacokinetics, drug absorption and distribution, protein binding and bioavailability. These fundamental areas of knowledge start with an understanding of the relationship between drugs interacting with target sites in the body and the effect produced (i.e. pharmacodynamic principles) and understanding the physiological and physicochemical factors that govern the effect of the body on drugs (metabolism), the movement of drugs around the body and the time course of exposure of body tissues and blood to drugs (i.e. pharmacokinetics). These principles involve developing concepts and models to explain drug activity in patients and to guide appropriate drug dosage selection. This unit will also explore reasons behind the factors affecting drug efficacy and variability in response to medicines among different individuals. The effects of disease, other drugs, demographics and the genetic basis for variable response will be introduced. Basic pharmacogenetic principles for explaining and predicting pharmacodynamic and pharmacokinetic variability in response will be explored.
3x3hr lectures/week, 2x3hr workshops/week
Workshop quiz (20%), Mid-term quiz (20%) and 2hr final exam (60%)
Shargel, Wu-Pong and Yu (2012). Applied Biopharmaceutics and Pharmacokinetics Birkett, DJ. (2010). Pharmacokinetics Made Easy (2nd ed) Licinio and Wong. Pharmacogenomics: The search for Individualised Therapies
3 credit points of Calculus, 6 credit points of Biochemistry, 12 credit points of Chemistry.