University of Sydney Handbooks - 2018 Archive

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Pharmacology Descriptions

PHARMACOLOGY

Advanced coursework and projects will be available in 2020 for students who complete this major.

Pharmacology major

A major in Pharmacology requires 48 credit points from this table including:
(i) 12 credit points of 1000-level core units
(ii) 12 credit points of 2000-level core units
(iii) 24 credit points of 3000-level core units

Pharmacology minor

A minor in Pharmacology requires 36 credit points from this table including:
(i) 12 credit points of 1000-level core units
(ii) 12 credit points of 2000-level core units
(iii) 12 credit points of 3000-level selective units

Units of study

The units of study are listed below.

1000-level units of study

Core
BIOL1007 From Molecules to Ecosystems

Credit points: 6 Teacher/Coordinator: Dr Emma Thompson Session: Semester 2,Summer Main Classes: Two lectures per week and online material and 12 x 3-hour practicals Prohibitions: BIOL1907 or BIOL1997 Assumed knowledge: HSC Biology. Students who have not completed HSC Biology (or equivalent) are strongly advised to take the Biology Bridging Course (offered in February). Assessment: Quizzes (10%), communication assessment (40%), skills tests (10%), summative final exam (40%) Mode of delivery: Normal (lecture/lab/tutorial) day
Paradigm shifts in biology have changed the emphasis from single biomolecule studies to complex systems of biomolecules, cells and their interrelationships in ecosystems of life. Such an integrated understanding of cells, biomolecules and ecosystems is key to innovations in biology. Life relies on organisation, communication, responsiveness and regulation at every level. Understanding biological mechanisms, improving human health and addressing the impact of human activity are the great challenges of the 21st century. This unit will investigate life at levels ranging from cells, and biomolecule ecosystems, through to complex natural and human ecosystems. You will explore the importance of homeostasis in health and the triggers that lead to disease and death. You will learn the methods of cellular, biomolecular, microbial and ecological investigation that allow us to understand life and discover how expanding tools have improved our capacity to manage and intervene in ecosystems for our own health and organisms in the environment that surround and support us . You will participate in inquiry-led practicals that reinforce the concepts in the unit. By doing this unit you will develop knowledge and skills that will enable you to play a role in finding global solutions that will impact our lives.
Textbooks
Please see unit outline on LMS
BIOL1907 From Molecules to Ecosystems (Advanced)

Credit points: 6 Teacher/Coordinator: Prof Pauline Ross Session: Semester 2 Classes: Two lectures per week and online material and 12 x 3-hour practicals Prohibitions: BIOL1007 or BIOL1997 Assumed knowledge: 85 or above in HSC Biology or equivalent Assessment: Quizzes (10%), communication assessment (40%), skills tests (10%), summative exam (40%) Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Paradigm shifts in biology have changed the emphasis from single biomolecule studies to complex systems of biomolecules, cells and their interrelationships in ecosystems of life. Such an integrated understanding of cells, biomolecules and ecosystems is key to innovations in biology. Life relies on organisation, communication, responsiveness and regulation at every level. Understanding biological mechanisms, improving human health and addressing the impact of human activity are the great challenges of the 21st century. This unit will investigate life at levels ranging from cells, and biomolecule ecosystems, through to complex natural and human ecosystems. You will explore the importance of homeostasis in health and the triggers that lead to disease and death. You will learn the methods of cellular, biomolecular, microbial and ecological investigation that allow us to understand life and discover how expanding tools have improved our capacity to manage and intervene in ecosystems for our own health and organisms in the environment that surround and support us . This unit of study has the same overall structure as BIOL1007 but material is discussed in greater detail and at a more advanced level. The content and nature of these components may vary from year to year.
Textbooks
Please see unit outline on LMS
BIOL1997 From Molecules to Ecosystems (SSP)

Credit points: 6 Teacher/Coordinator: Dr Dale Hancock Session: Semester 2 Classes: Two lectures per week and online material Prohibitions: BIOL1007 or BIOL1907 Assumed knowledge: 90 or above in HSC Biology or equivalent Assessment: One 2-hour exam (50%), project report which includes written report and presentation (50%) Practical field work: As advised and required by the project; approximately 30-36 hours of research project in the laboratory or field Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Paradigm shifts in biology have changed the emphasis from single biomolecule studies to complex systems of biomolecules, cells and their interrelationships in ecosystems of life. Such an integrated understanding of cells, biomolecules and ecosystems is key to innovations in biology. Life relies on organisation, communication, responsiveness and regulation at every level. Understanding biological mechanisms, improving human health and addressing the impact of human activity are the great challenges of the 21st century. This unit will investigate life at levels ranging from cells, and biomolecule ecosystems, through to complex natural and human ecosystems. You will explore the importance of homeostasis in health and the triggers that lead to disease and death. You will learn the methods of cellular, biomolecular, microbial and ecological investigation that allow us to understand life and intervene in ecosystems to improve health. The same theory will be covered as in the advanced stream but in this Special Studies Unit, the practical component is a research project. The research will be either a synthetic biology project investigating genetically engineered organisms or organismal/ecosystems biology. Students will have the opportunity to develop higher level generic skills in computing, communication, critical analysis, problem solving, data analysis and experimental design.
Textbooks
Please see unit outline on LMS
CHEM1011 Fundamentals of Chemistry 1A

Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1 Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1111 or CHEM1911 or CHEM1991 Assumed knowledge: There is no assumed knowledge of chemistry for this unit of study but students who have not completed HSC Chemistry (or equivalent) are strongly advised to take the Chemistry Bridging Course (offered in February). Assessment: quizzes, attendance, laboratory log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Students who have not completed HSC Chemistry (or equivalent) are strongly advised to take the Chemistry Bridging Course (offered in February, and online year-round, see http://sydney.edu.au/science/chemistry/studying-chemistry/bridging-course.shtml).
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in the life, medical and physical sciences, engineering, and industrial processes. This unit of study will equip you with the fundamental knowledge and skills in chemistry for broad application. You will learn about atomic theory, structure and bonding, equilibrium, processes occurring in solutions, and the functional groups of molecules. You will develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions about the chemical nature and processes occurring around you. Through inquiry, observation and measurement, you will better understand natural and physical world and will be able to apply this understanding to real-world problems and solutions. This unit of study is directed toward students whose chemical background is weak (or non-existent). Compared to the mainstream Chemistry 1A, the theory component of this unit begins with more fundamental concepts, and does not cover, or goes into less detail about some topics. Progression to intermediate chemistry from this unit and Fundamentals of Chemistry 1B requires completion of an online supplementary course.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1111 Chemistry 1A

Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1,Semester 2,Summer Main Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1011 or CHEM1911 or CHEM1991 Assumed knowledge: Students who have not completed HSC Chemistry (or equivalent) and HSC Mathematics (or equivalent) are strongly advised to take the Chemistry and Mathematics Bridging Courses (offered in February) Assessment: quizzes, attendance, laboratory log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Students who have not completed secondary school chemistry are strongly advised to instead complete Fundamentals of Chemistry 1A in the first semester of the calendar year (unless you require 12 credit points of Chemistry and are commencing in semester 2). You should also take the Chemistry Bridging Course in advance (offered in February, and online year-round http://sydney.edu.au/science/chemistry/studying-chemistry/bridging-course.shtml).
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in the life, medical and physical sciences, engineering, and industrial processes. This unit of study will further develop your knowledge and skills in chemistry for application to life and medical sciences, engineering, and further study in chemistry. You will learn about nuclear and radiation chemistry, wave theory, atomic orbitals, spectroscopy, bonding, enthalpy and entropy, equilibrium, processes occurring in solutions, and the functional groups in carbon chemistry. You will develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions like how do dyes work, how do we desalinate water, how do we measure the acid content in foods, how do we get the blue in a blueprint, and how do we extract natural products from plants? Through inquiry, observation and measurement, you will understand the 'why' and the 'how' of the natural and physical world and will be able to apply this understanding to real-world problems and solutions. This unit of study is directed toward students with a satisfactory prior knowledge of the HSC chemistry course.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1911 Chemistry 1A (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1 Classes: 3x1-hr lectures and 1x1-hr tutorial per week; 1x3-hr practical per week for 9 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1011 or CHEM1111 or CHEM1991 Assumed knowledge: 80 or above in HSC Chemistry or equivalent Assessment: quizzes, attendance, laboratory log book, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in sciences, engineering, and industrial processes. This unit of study will further develop your knowledge and skills in chemistry for broad application, including further study in chemistry. You will learn about nuclear and radiation chemistry, wave theory, atomic orbitals, spectroscopy, bonding, enthalpy and entropy, equilibrium, processes occurring in solutions, and the functional groups of molecules. You will develop experimental design, conduct and analysis skills in chemistry through experiments that ask and answer questions about the chemical nature and processes occurring around you. Through inquiry, observation and measurement, you will better understand natural and physical world and will be able to apply this understanding to real-world problems and solutions. This unit of study is directed toward students with a good secondary performance both overall and in chemistry or science. Students in this category are expected to do this unit rather than Chemistry 1A. Compared to the mainstream Chemistry 1A, the theory component of this unit provides a higher level of academic rigour and makes broader connections between topics.
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)
CHEM1991 Chemistry 1A (Special Studies Program)

Credit points: 6 Teacher/Coordinator: Dr Toby Hudson Session: Semester 1 Classes: 3x1-hr lectures; 1x1-hr tutorial per week; 1x3hr practical per week for 12 weeks Prohibitions: CHEM1001 or CHEM1101 or CHEM1901 or CHEM1903 or CHEM1109 or CHEM1011 or CHEM1111 or CHEM1911 Assumed knowledge: 90 or above in HSC Chemistry or equivalent Assessment: quizzes, attendance, presentations, exam Mode of delivery: Normal (lecture/lab/tutorial) day
Note: Department permission required for enrolment
Chemistry describes how and why things happen from a molecular perspective. Chemistry underpins all aspects of the natural and physical world, and provides the basis for new technologies and advances in the life, medical and physical sciences, engineering, and industrial processes. This unit of study will further develop your knowledge and skills in chemistry for application to life and medical sciences, engineering, and further study in chemistry. You will learn about nuclear and radiation chemistry, wave theory, atomic orbitals, spectroscopy, bonding, enthalpy and entropy, equilibrium, processes occurring in solutions, and the functional groups in carbon chemistry. You will develop experimental design, conduct and analysis skills in chemistry in small group projects. The laboratory program is designed to extend students who already have chemistry laboratory experience, and particularly caters for students who already show a passion and enthusiasm for research chemistry, as well as aptitude as demonstrated by high school chemistry results. Entry to Chemistry 1A (Special Studies Program) is restricted to a small number of students with an excellent school record in Chemistry, and applications must be made to the School of Chemistry. The practical work syllabus for Chemistry 1A (Special Studies Program) is very different from that for Chemistry 1A and Chemistry 1A (Advanced) and consists of special project-based laboratory exercises. All other unit of study details are the same as those for Chemistry 1A (Advanced).
Textbooks
Recommended textbook: Blackman, Bottle, Schmid, Mocerino and Wille,Chemistry, 3rd Edition, 2015 (John Wiley) ISBN: 978-0-7303-1105-8 (paperback) or 978-0-7303-2492-8 (e-text)

2000-level units of study

Core
PCOL2011 Pharmacology Fundamentals

Credit points: 6 Teacher/Coordinator: Dr Hilary Lloyd Session: Semester 1 Classes: Lectures (2 x1 hr per week); wet and dry labs (5 x4 hrs), data anaylsis tutorials (2 x 2 hrs); workshops (6 x 2 hrs) Prerequisites: 6cp from CHEM1XXX Prohibitions: PCOL2555 orBMED2401 or BMED2402 or BMED2403 or BMED2404 or BMED2405 or BMED2406 or BMED2801 or BMED2802 or BMED2803 or BMED2804 or BMED2805 or BMED2806 or BMED2807 or BMED2808 Assumed knowledge: BIOL1XXX or MBLG1XX1 Assessment: In-semester (40%), which consists of 4 x on-line quizzes, 2 x lab reports, 3 x research topics, 1 x oral presentation, end-of-semester examination (60%), which consists of multiple choice and short answer questions Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study provides the fundamental grounding in four basic areas in Pharmacology: (1) principles of drug action (2) pharmacokinetics and drug metabolism (3) experimental design and autonomic pharmacology, and (4) drug design. The delivery of material involves lectures, practicals, computer-aided learning and problem-based workshops. Practical classes provide students with the opportunity of acquiring technical experience and teamwork skills. Problem-based workshops are based on real-life scenarios of drug use in the community. These workshops require students to integrate information obtained in lectures in order to provide solutions to the problems. Online quizzes accompany each module and are to encourage continued learning throughout the semester.
Textbooks
Rang and Dale's Pharmacology, 8th Edition. H. P. Rang, J. M. Ritter, R. J. Flower, and G. Henderson, (Elsevier 2016 ). Medical Pharmacology at a Glance, 7th edn M.J. Neal: (Blackwell Scientific Publications, 2012).
PCOL2012 Pharmacology: Drugs and People

Credit points: 6 Teacher/Coordinator: Dr Hilary Lloyd Session: Semester 2 Classes: Lectures (2x1 hr per week); wet and dry labs (5 x 4 hrs), data analysis tutorials (2 x 2 hrs); workshops (6 x 2 hrs) Prerequisites: 6cp from CHEM1XXX Prohibitions: PCOL2555 Assumed knowledge: (BIOL1XXX or MBLG1XX1) and PCOL2011 Assessment: In-semester (40%), which consists of 4 x on-line quizzes, 2 x lab reports, 3 x research topics, 1 x oral presentation, end-of-semester examination (60%), which consists of multiple choice and short answer questions Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study examines four important areas of Pharmacology: (1) Principles of drug action in the nervous system; (2) Drug abuse, addiction and analgesia; (3) Drug treatment of allergies and GI disorders; (4) Introduction to drug discovery and development. The delivery of material involves lectures, practicals, computer-aided learning and problem-based workshops. Practical classes provide students with the opportunity of acquiring technical experience and teamwork skills. Problem-based workshops are based on real-life scenarios of drug use in the community. These workshops require students to apply information obtained in lectures and readings in order to 'solve' the problems. Workshop activities will include oral presentations.
Textbooks
Rang and Dale's Pharmacology, 8th Edition. H. P. Rang, J. M. Ritter, R. J. Flower, and G. Henderson, (Elsevier 2015 ). Medical Pharmacology at a Glance, 7th edn M.J. Neal: (Blackwell Scientific Publications, 2012).
MEDS2002 to be developed for offering in 2019 (MEDS coded units of study are only available to students in the Medical Science stream).

3000-level units of study

Major core
PCOL3011 Toxicology

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 1 Classes: Two 1 hour lectures per week and one 3 hour tutorial/practical every 2 weeks and two practical sessions each 3 hours in length. Prerequisites: PCOL2011 or (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3911 Assessment: One 2 hour exam, tutorial presentations, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the discipline of toxicology. The study of toxicology is central to the assessment of drug safety in drug development and in the explanation of toxicology associated with registered drugs (adverse drug reactions) and drug-drug interactions. These issues as well as the pharmacogenetic basis of adverse reactions will be considered. Environmental toxicology, particularly toxic reactions to environmental agents such as asbestos and pesticides, and target organ toxicology (lung, liver, CNS) are also covered. The diverse world of plants and animal toxins will also be explored. As a final consequence of exposure to many toxicants, the biology and causes of cancer are discussed. As part of the unit students are introduced to basic ideas about the collection and analysis of data from human and animal populations, both in the structured situation of clinical trials, forensic problems and in analysis of epidemiological data.
Textbooks
Klaasen, Curtis D. Casarett and Doull's Essentials of Toxicology 2 ed. McGraw Hill. 2010, or, by the same authors: Toxicology: The Basic Science of Poisons. 7 ed. McGraw Hill. 2008.
PCOL3911 Toxicology (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 1 Classes: Two 1 hour lectures per week and one 3 hour tutorial/practical every second week. and two practical sessions each 3 hours in length Prerequisites: A mark of 70 or above in [PCOL2011 or (BMED2401 and an additional 12 credit points of BMED240X)] Prohibitions: PCOL3011 Assessment: One 2 hour exam, tutorial presentations, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3011. Students will be set special advanced assignments and additional practical data management activities related to the material covered in lectures and practical work. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Klaasen, Curtis D. Casarett and Doull's Essentials of Toxicology 3rd ed. McGraw Hill. 2015.. or, by the same authors: Toxicology: The Basic Science of Poisons. 8th ed. McGraw Hill. 2013.
PCOL3012 Drug Design and Development

Credit points: 6 Teacher/Coordinator: Dr Brent McParland Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: [PCOL2011 or (BMED2401 and an additional 12 credit points of BMED240X)] or 12 credit points of BCMB2XXX Prohibitions: PCOL3912 Assessment: One 2 hour exam, class and online quizzes, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the field of medicinal chemistry associated with drug design and development. The course covers the fundamental aspects of drug discovery and development with reference to the essentials of chemistry and illustrates drug development with examples that include neuraminidase inhibitors and angiotensin converting enzyme inhibitors. The role of computers in drug design is emphasised by classwork and assignments on molecular modelling and structure-activity relationships. The course also extends to a section on the design of diverse pharmacological agents which include compounds for imaging by positron emission tomography (PET), and kinase inhibitors.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.
PCOL3912 Drug Design and Development (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Brent McParland Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: A mark of 70 or above in [PCOL2011 or (BMED2401 and an additional 12 credit points from BMED240X)] or a mark of 70 or above in 12 credit points of BCMB2XXX Prohibitions: PCOL3012 Assessment: One 2 hour exam, in class and online quizzes, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3012. Students will be set special advanced assignments related to the material covered in core areas. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.
PCOL3021 Drug Therapy

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 2 Classes: Two 1 hour lectures per week, three 2 hour tutorials, three 3 hour practicals, elective project (equivalent to four 3 hour practicals) Prerequisites: PCOL2011 or (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3921 Assessment: One 2 hour exam, in lecture tests, practical assignment and elective project (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study extends on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of the scientific basis of current and novel approaches to pharmacological treatment for major health challenges of the 21st century. Lecture topics, tutorials and laboratory sessions cover drug treatment of arthritis, cardiovascular disorders, cancer, diabetes and protein misfolding disorders. New approaches to the development of next-generation targeted drugs are also introduced. As part of this course all students will extend the practical skills in understanding scientific literature, statistical analysis, critical problem solving and analytical thinking. Each student will conduct a capstone elective project (laboratory or literature-based) in applied pharmacology supervised by academic members of the department.
Textbooks
Rang and Dale's Pharmacology, 7th edn; Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson (Churchill Livingstone).
PCOL3921 Drug Therapy (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 2 Classes: Two 1 hour lectures per week, three 2 hour tutorials-advanced material, three 3 hour practicals, elective project (equivalent to four 3 hour practicals, preference given for laboratory-based project). Prerequisites: A mark of 70 or above in [PCOL2011 or (BMED2401 and an additional 12 credit points from BMED240X)] Prohibitions: PCOL3021 Assessment: One 2 hour exam, two lecture tests, practical assignment and elective project (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the same lecture series as PCOL3021. The tutorials and practical sessions will extend the work provided in PCOL321 to challenge deeper learning in the effect of drug therapy on pathophysiology of chronic diseases.
Textbooks
Rang and Dale's Pharmacology, 7th edn; Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson (Churchill Livingstone).
PCOL3022 Neuropharmacology

Credit points: 6 Teacher/Coordinator: A/Prof Jonathon Arnold Session: Semester 2 Classes: Two 1 hour lectures per week, five 1 hour tutorials, three 3 hour practicals, elective project (equivalent to three 4 hour practicals). Prohibitions: PCOL3922 Assumed knowledge: PCOL2011 or (BMED2401 and an additional 12 credit points of BMED240X) Assessment: One 2 hour theory exam, tutorial presentation, practical report, lecture quizzes and elective project (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study builds on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of neuropharmacology. The neuropharmacology of the major neurotransmitters and their role in neuropsychiatric diseases is explored together with the treatment of conditions such as Alzheimer's disease, movement disorders, stroke, depression, anxiety, epilepsy, pain and schizophrenia. Elective projects relate to current research areas in Pharmacology.
Textbooks
Nestler, EJ, Hyman, SE and Malenka, RC. Molecular Neuropharmacology: A Foundations for Clinical Neuroscience, 2nd ed. McGraw Hill, 2009.
PCOL3922 Neuropharmacology (Advanced)

Credit points: 6 Teacher/Coordinator: A/Prof Jonathon Arnold Session: Semester 2 Classes: Two 1 hour lectures per week, five 1 hour tutorials, three 3 hour practicals, elective project (equivalent to three 4 hour practicals). Prerequisites: An annual average mark of 70 or above in the previous year Prohibitions: PCOL3022 Assumed knowledge: PCOL2011 or (BMED2401 and an additional 12 credit points from BMED240X) Assessment: One 2 hour theory exam, tutorial presentation, practical report, lecture quizzes and elective project (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study builds on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of neuropharmacology. The neuropharmacology of the major neurotransmitters and their role in neuropsychiatric diseases is explored together with the treatment of conditions such as Alzheimer's disease, movement disorders, stroke, depression, anxiety, epilepsy, pain and schizophrenia. Elective projects relate to current research areas in Pharmacology.
Textbooks
Nestler, EJ, Hyman, SE and Malenka, RC. Molecular Neuropharmacology: A Foundations for Clinical Neuroscience, 2nd ed. McGraw Hill, 2009.
Minor selective
PCOL3011 Toxicology

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 1 Classes: Two 1 hour lectures per week and one 3 hour tutorial/practical every 2 weeks and two practical sessions each 3 hours in length. Prerequisites: PCOL2011 or (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3911 Assessment: One 2 hour exam, tutorial presentations, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the discipline of toxicology. The study of toxicology is central to the assessment of drug safety in drug development and in the explanation of toxicology associated with registered drugs (adverse drug reactions) and drug-drug interactions. These issues as well as the pharmacogenetic basis of adverse reactions will be considered. Environmental toxicology, particularly toxic reactions to environmental agents such as asbestos and pesticides, and target organ toxicology (lung, liver, CNS) are also covered. The diverse world of plants and animal toxins will also be explored. As a final consequence of exposure to many toxicants, the biology and causes of cancer are discussed. As part of the unit students are introduced to basic ideas about the collection and analysis of data from human and animal populations, both in the structured situation of clinical trials, forensic problems and in analysis of epidemiological data.
Textbooks
Klaasen, Curtis D. Casarett and Doull's Essentials of Toxicology 2 ed. McGraw Hill. 2010, or, by the same authors: Toxicology: The Basic Science of Poisons. 7 ed. McGraw Hill. 2008.
PCOL3911 Toxicology (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 1 Classes: Two 1 hour lectures per week and one 3 hour tutorial/practical every second week. and two practical sessions each 3 hours in length Prerequisites: A mark of 70 or above in [PCOL2011 or (BMED2401 and an additional 12 credit points of BMED240X)] Prohibitions: PCOL3011 Assessment: One 2 hour exam, tutorial presentations, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3011. Students will be set special advanced assignments and additional practical data management activities related to the material covered in lectures and practical work. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Klaasen, Curtis D. Casarett and Doull's Essentials of Toxicology 3rd ed. McGraw Hill. 2015.. or, by the same authors: Toxicology: The Basic Science of Poisons. 8th ed. McGraw Hill. 2013.
PCOL3012 Drug Design and Development

Credit points: 6 Teacher/Coordinator: Dr Brent McParland Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: [PCOL2011 or (BMED2401 and an additional 12 credit points of BMED240X)] or 12 credit points of BCMB2XXX Prohibitions: PCOL3912 Assessment: One 2 hour exam, class and online quizzes, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study is designed to introduce students with a basic understanding of pharmacology to the field of medicinal chemistry associated with drug design and development. The course covers the fundamental aspects of drug discovery and development with reference to the essentials of chemistry and illustrates drug development with examples that include neuraminidase inhibitors and angiotensin converting enzyme inhibitors. The role of computers in drug design is emphasised by classwork and assignments on molecular modelling and structure-activity relationships. The course also extends to a section on the design of diverse pharmacological agents which include compounds for imaging by positron emission tomography (PET), and kinase inhibitors.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.
PCOL3912 Drug Design and Development (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Brent McParland Session: Semester 1 Classes: Two 1 hour lectures and one 3 hour tutorial/practical per week. Prerequisites: A mark of 70 or above in [PCOL2011 or (BMED2401 and an additional 12 credit points from BMED240X)] or a mark of 70 or above in 12 credit points of BCMB2XXX Prohibitions: PCOL3012 Assessment: One 2 hour exam, in class and online quizzes, assignments (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the lecture and practical components of PCOL3012. Students will be set special advanced assignments related to the material covered in core areas. These may also involve advanced practical work or detailed investigation of a theoretical problem.
Textbooks
Patrick, Graham L. An Introduction to Medicinal Chemistry. 5th edition. Oxford University Press. 2013.
PCOL3021 Drug Therapy

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 2 Classes: Two 1 hour lectures per week, three 2 hour tutorials, three 3 hour practicals, elective project (equivalent to four 3 hour practicals) Prerequisites: PCOL2011 or (BMED2401 and 12 additional credit points of BMED240X) Prohibitions: PCOL3921 Assessment: One 2 hour exam, in lecture tests, practical assignment and elective project (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study extends on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of the scientific basis of current and novel approaches to pharmacological treatment for major health challenges of the 21st century. Lecture topics, tutorials and laboratory sessions cover drug treatment of arthritis, cardiovascular disorders, cancer, diabetes and protein misfolding disorders. New approaches to the development of next-generation targeted drugs are also introduced. As part of this course all students will extend the practical skills in understanding scientific literature, statistical analysis, critical problem solving and analytical thinking. Each student will conduct a capstone elective project (laboratory or literature-based) in applied pharmacology supervised by academic members of the department.
Textbooks
Rang and Dale's Pharmacology, 7th edn; Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson (Churchill Livingstone).
PCOL3921 Drug Therapy (Advanced)

Credit points: 6 Teacher/Coordinator: Dr Slade Matthews Session: Semester 2 Classes: Two 1 hour lectures per week, three 2 hour tutorials-advanced material, three 3 hour practicals, elective project (equivalent to four 3 hour practicals, preference given for laboratory-based project). Prerequisites: A mark of 70 or above in [PCOL2011 or (BMED2401 and an additional 12 credit points from BMED240X)] Prohibitions: PCOL3021 Assessment: One 2 hour exam, two lecture tests, practical assignment and elective project (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit will consist of the same lecture series as PCOL3021. The tutorials and practical sessions will extend the work provided in PCOL321 to challenge deeper learning in the effect of drug therapy on pathophysiology of chronic diseases.
Textbooks
Rang and Dale's Pharmacology, 7th edn; Drs. Humphrey P. Rang, Maureen M. Dale, James M. Ritter, Rod Flower, and Graeme Henderson (Churchill Livingstone).
PCOL3022 Neuropharmacology

Credit points: 6 Teacher/Coordinator: A/Prof Jonathon Arnold Session: Semester 2 Classes: Two 1 hour lectures per week, five 1 hour tutorials, three 3 hour practicals, elective project (equivalent to three 4 hour practicals). Prohibitions: PCOL3922 Assumed knowledge: PCOL2011 or (BMED2401 and an additional 12 credit points of BMED240X) Assessment: One 2 hour theory exam, tutorial presentation, practical report, lecture quizzes and elective project (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study builds on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of neuropharmacology. The neuropharmacology of the major neurotransmitters and their role in neuropsychiatric diseases is explored together with the treatment of conditions such as Alzheimer's disease, movement disorders, stroke, depression, anxiety, epilepsy, pain and schizophrenia. Elective projects relate to current research areas in Pharmacology.
Textbooks
Nestler, EJ, Hyman, SE and Malenka, RC. Molecular Neuropharmacology: A Foundations for Clinical Neuroscience, 2nd ed. McGraw Hill, 2009.
PCOL3922 Neuropharmacology (Advanced)

Credit points: 6 Teacher/Coordinator: A/Prof Jonathon Arnold Session: Semester 2 Classes: Two 1 hour lectures per week, five 1 hour tutorials, three 3 hour practicals, elective project (equivalent to three 4 hour practicals). Prerequisites: An annual average mark of 70 or above in the previous year Prohibitions: PCOL3022 Assumed knowledge: PCOL2011 or (BMED2401 and an additional 12 credit points from BMED240X) Assessment: One 2 hour theory exam, tutorial presentation, practical report, lecture quizzes and elective project (100%) Mode of delivery: Normal (lecture/lab/tutorial) day
This unit of study builds on pharmacological knowledge acquired in the intermediate PCOL and BMED units of study with a major emphasis on gaining an understanding of neuropharmacology. The neuropharmacology of the major neurotransmitters and their role in neuropsychiatric diseases is explored together with the treatment of conditions such as Alzheimer's disease, movement disorders, stroke, depression, anxiety, epilepsy, pain and schizophrenia. Elective projects relate to current research areas in Pharmacology.
Textbooks
Nestler, EJ, Hyman, SE and Malenka, RC. Molecular Neuropharmacology: A Foundations for Clinical Neuroscience, 2nd ed. McGraw Hill, 2009.