New projects in Medical Physics

3 December 2012

Associate Professor Yves De Deene, a recent addition to the Institute of Medical Physics has relished the opportunity of working at Sydney University and hit the ground running by actively contributing to the School of Physics and the Faculty of Science at conferences and in papers.

He is setting up some new research projects that he has been working on in Belgium and which are focused on quantitative nuclear magnetic resonance imaging (MRI) and spectroscopy (MRS).

Apart from the acquisition of diagnostic images with high image contrast between different types of soft tissues, MRI can also provide quantitative maps of Tissue Elasticity, Temperature, Magnetization, Blood Flow, Radiation Doses, Fibre Densities, Tissue and Blood Oxygenation and Metabolic concentrations.

Associate Professor De Deene is currently aiming at improving these techniques and to obtain a better understanding of the physical correlation of these MRI parameters with the tissue microstructure and tumour physiology. The ultimate aim is to incorporate this quantitative biological information into the radiation treatment planning of cancer patients. In addition, he is also constructing new optical scanners and 3D radiation dosimeters for clinical radiation dosimetry.

Nanoparticles are used in hyperpolarized gas MRI for lung perfusion and molecular imaging.
Nanoparticles are used in hyperpolarized gas MRI for lung perfusion and molecular imaging.

A new NMR spectrometer with a 9.4 Tesla superconducting magnet is being shipped from Belgium to the School of Physics and will arrive in Mid December 2012. With the new NMR spectrometer, Associate Professor De Deene plans to continue with five major research lines in order to optimise treatment:

  1. 3D Radiation dosimetry using polymer gel dosimeters in order to better model radiation treatments
  2. Non-Invasive microstructure analysis by use of quantitive MRI for the assessment of micro structural parameters in cells.
  3. Non-Invasive mapping of tumour physiology where physical maps are created, displaying oxygen tension and Choline, a cancer indicator.
  4. Hyperpolarised gas MRI for lung perfusion and molecular imaging
  5. Low Field Small Animal MRI Irradiator for the treatment of a subject while being imaged.

Associate Professor De Deene will begin his research in earnest early 2013 and is currently applying for grants and searching for students to participate and join in the groups' projects.

Contact: Tom Gordon

Phone: 02 9351 3201

Email: 0c015f21114f562f36395c48300b37365c1b251516783225104f031e