Our team seek to understand the spatial and temporal mechanisms involved in the onset and progress of colorectal cancer by using state-of-the-art multidimensional microscopy and 3-D correlative imaging techniques. In this way, novel ultrastsructural information over micrometre-to-nanometre scales can be gathered to underpin the development and application of new targeted drug delivery strategies of for colorectal cancer.Other related work focuses on the development of 4-D simulation models of the colorectal tumour's in-vivo microenvironment in relevant organoid and animal models. In this work we explore the structure-function relationship of different subcellular compartments and molecules in various vascular models.
This work will build on A/Prof. Braet's seminal work that cover the areas of structural biology, cancer biology, cell membrane biology, nanobiology, and chemical biology.
The opportunity ID for this research opportunity is 1502