Oxidative stress is associated with all diseases of ageing, and there is therefore a need for better tools to identify and quantify the condition. We are developing novel fluorescent sensors of oxidative stress.
This project will involve the design, synthesis and application of small molecule redox sensors based on organic molecules. Sensors will contain a fluorophore (or multiple fluorophores) tethered to both a redox-sensitive group and a targeting domain. Following synthesis of these molecules, we will study the photophysical properties of our systems, which will enable us to improve upon our probe design. Promising probes will be used to study models of disease in cultured cells. We will then work with collaborators to use our probes in more complex biological systems.
This project is suited to students with an interest in the applications of chemistry in biology. Research will involve chemical synthesis, spectroscopy and simple cellular studies, with collaborations in place for the study of more complex biological systems.
In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:
The opportunity ID for this research opportunity is 1514