The project aims to design and develop curcumin nanoparticles using various fabrication approaches, including liposome-nanoparticle assemblies and polymer-coated nanoparticles. The in vitro anti-cancer and anti-microbial activities of such curcumin nanoparticles will be assessed. The project will develop curcumin nanoparticles that target cancer cells by immobilization antibodies onto the surface of nanoparticles.
Curcumin, a polyphenol extract from plant and the active compound of the Indian spice turmeric, has a broad spectrum of pharmacological activities, including anti-microbial, anti-oxidant, anti-inflammatory and anti-cancer. However, its low water-solubility, therefore inadequate bioavailability, remains a major hurdle that limits its medical applications. My team is developing and characterizing mono-dispersed and non-aggregated curcumin nano-particles to increase curcumin's bioavailability and to promote its anti-cancer and anti-microbial effects. The results demonstrate that in a size-depending manner, nano-formulation of curcumin increases its skin penetration as well as its uptake rate into different cancer cell lines.
This is a joint project between Faculty of Pharmacy and Department of Physiology, University of Sydney) and School of Pharmacy, University of Technology, Sydney.
The opportunity ID for this research opportunity is 1720