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Novel therapies for treating progressive chronic kidney disease


The use of DNA vaccination and regulatory cells to treat progressive kidney disease.


Professor David Harris.

Research location

Westmead - Westmead Institute for Medical Research

Program type



This project is examining the use of regulatory lymphocytes, regulatory macrophages and regulatory dendritic cells as treatments for progressive  kidney disease. Regulatory phenotype is achieved by in vitro transduction of regulatory genes, or by application of cytokines which  determine the regulatory phenotype. DNA vaccination using genes identified to be important players in the progression of kidney disease will also be used as a novel approach to therapy.  The effect on treatment efficacy of vaccination against multiple genes will be examined.  These novel therapies are being examined in rodent models of diabetic and non-diabetic kidney disease.  It is anticipated that this research will ultimately lead to the definition therapies to be applied to human kidney disease.

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Opportunity ID

The opportunity ID for this research opportunity is 201