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Nature is a master of self-assembly, constructing functional nanoscale architectures from simple protein building blocks. Using synthetic chemistry, we can harness the power of self-assembling proteins to create new architectures for catalysis.
We have several projects available that involve chemical modification of encapsulins, bacterial proteins that spontaneously assemble into hollow ~30 nm shells (see Nat. Commun. 2018, 9, 1311). A unique feature of encapsulins is their ability to house other molecules, in a targeted binding process that is mediated by a simple peptide tag. These projects will involve creating nano-sized reaction vessels by functionalising the interior of these shells with synthetic molecules. These encapsulin compartments will then be probed in a range of functional assays to establish new applications in catalysis and synthetic biology.
This project is in collaboration with Dr Tobias Giessen (University of Michigan, USA).
These projects are suited for students who are interested in the interface between chemistry and biology. Previous experience in organic chemistry or molecular biology is desirable. Feel free to contact Dr Lau to learn more about the project, the application process, and potential funding opportunities.
In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:
The opportunity ID for this research opportunity is 2400