Research Supervisor Connect
CRISPR genome editing has revolutionized how we do basic research. This technique can be scaled up so we can assess the role of each human gene in virtually any biological process. One of the major limitations of this technique is that the primary endpoint for these kinds of screens is cell survival. We have made progress in developing new more functional screens to evaluate cellular signal transduction responses at the genome scale. This project involves further developing and applying these new genome scale technologies to investigate major human disease pathways. This work will also be designed to quickly lead to new medicine.
A complimentary scholarship for this project may be available through a competitive process. To find out more, refer to the Faculty of Science Postgraduate Research Excellence Award and contact Professor Greg Neely directly.
Research location: Charles Perkins Center
Evaluating human cellular responses functionally and at the genome scale has only recently been possible. This project is flexible and involves developing and using new genome editing technologies to investigate cellular responses to pain, inflammation, growth factors, neuropeptides, or other medically relevant stimuli using functional readouts. The techniques employed for this project will include CRISPR genome editing, cellular and molecular biology, synthetic virus design and generation, fluorescent activated cell sorting, lipid nanoparticle delivery of RNA, and potentially human stem cell derived organoids and / or animal studies.
This project is open for PhD candidates.
The opportunity ID for this research opportunity is 3331