Respiratory infection is the number one cause of death world-wide with limited therapies other than tablet or intravenous injection. This multi-faceted PhD project will focus on developing inhalable therapies that can be used to treat a series of lung diseases. You will gain experience in particle engineering, cell biology and aerosol science.
Cystic fibrosis (CF) is an inherited disease that affects the lungs. In healthy lungs the mucus present is normally watery, but in CF patients an abnormal gene causes mucus to become thick and sticky, it builds up in the lungs and blocks the airways. This makes it easy for bacteria to grow and leads to repeated serious lung infections. Over time, both these adverse effects can become life threatening. Respiratory failure is in fact the most common cause of death in people with CF. Although mannitol as already been identified as a potential therapeutic agent for the treatment of CF, to the authors knowledge there is no anti-inflammatory on the market that can be delivered conveniently and directly the to the lungs via inhalation. Until now nebulizers have been used as the only alternative to high oral doses (with consequently high risk of side effects), to deliver of anti-inflammatory to the lungs. This therapy is very costly, time consuming for the patient and furthermore mostly inefficacious. The proposed research project aims to devise a novel dual-action formulation to be delivered directly to the site of the disease and that could be efficacious on both the major symptoms presents in CF patients: the build up of thick mucus and the bacterial inflammation. Delivering both therapeutics in one single dose will have many advantages: having two therapeutic drugs together will relief the CF patients of the immediate symptoms; will increase patient compliance and being a portable device will give CF patient more freedom and independence.
Research Plan: In order to understand the mannitol-antibiotic dry powder system, the project is divided the study into four primary sections:
Please see website: Respiratory Technology at the Woolcock Institute of Medical Research
The opportunity ID for this research opportunity is 5