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Image processing for understanding cell biology

In this project we aim to develop novel image and video processing algorithms and pipelines to better understand cell biology. more...

Supervisor(s): Khushi, Matloob (Dr)

Investigating the role of a novel RNA binding protein in telomerase activity

We have identified a role for a novel RNA binding protein in telomerase biogenesis and recruitment to telomeres. We aim to investigate how this protein functions in this context usi more...

Supervisor(s): Pickett, Hilda (Associate Professor)

How to stop an epileptic seizure - looking for the right molecules to target

Over 400 proteins are implicated in epilepsy. This project involves interrogating models of epilepsy to determine which are the key pathways and molecular mechanisms which could be more...

Supervisor(s): Graham, Mark (Dr)

How do molecules make memories? Understanding synaptic plasticity at the level of protein pathways and signalling.

This project aims to discover and validate new molecular mechanisms of how synaptic plasticity, which underlies learning and memory, is regulated by protein interactions and phospho more...

Supervisor(s): Graham, Mark (Dr)

Pathways to therapies in blinding genetic retinal eye diseases

In this project, novel disease genes and variants are identified that cause blinding retinal eye diseases. Cellular, gene editing, proteomic and animal model approaches are taken to more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

Genomic medicine for unravelling the challenges of pathogenesis and treatment of blindness due to childhood cataract and glaucoma

Novel disease genes and variants are identified that contribute to the blinding eye diseases of childhood cataract and glaucoma.  In this project further novel variants will be more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

HUMAN MINIBRAINS GROWN FROM STEM CELLS

This project will involve CRISPR genome editing strategies combined with human stem cell derived mini-brains to investigate new neuronal factors that control development, cognitive more...

Supervisor(s): Neely, Greg (Professor)

Gene function and RNA processing in gut endoderm development

This project aims to unravel the impact of RNA processing on the function the targets of a RNA binding protein in the development of the embryonic gut and the associated organs. more...

Supervisor(s): Fossat, Nicolas (Dr), Tam, Patrick (Professor)

Generation of a sheep model of Batten disease using the CRISPR/Cas9 genome editing system

The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are a group of fatal neurodegenerative inherited diseases in humans and animals (http://bdsra.org/). There is no cure, but more...

Supervisor(s): Tammen, Imke (Associate Professor), Grupen, Christopher Gerald (Associate Professor)

Gene therapy for genetic and acquired diseases of the liver and haematopoietic system.

We are working on developing new therapies for the treatment of genetic and acquired diseases of the liver and haematopoietic system. The Gene Therapy Research Unit has a diverse se more...

Supervisor(s): Alexander, Ian (Professor), Ginn, Samantha (Dr), Logan, Grant (Dr)