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The role of a novel mutant gene in dementia and motor neuron disease

We have identified a new gene that when mutated causes dementia and motor neuron disease (MND), diseases that are currently incurable. This project will examine how this mutated gen more...

Supervisor(s): Dobson-Stone, Carol (Dr)

Sleep and Cancer: The role of intermittent hypoxia

Background: Recent epidemiological studies have shown that patients with obstructive sleep apnoea (OSA) have higher rates of cancer and cancer mortality however the underlying mecha more...

Supervisor(s): Cook, Kristina (Dr), Cistulli, Peter (Professor)

The DNA replication stress response

Genome integrity in human cells is maintained through the coordinated functions of the DNA damage response. We study these processes with particular interest in the pathways that re more...

Supervisor(s): Cesare, Tony (Dr)

Pathways to therapies in blinding genetic retinal eye diseases

In this project, novel disease genes and variants are identified that cause blinding retinal eye diseases. Cellular, gene editing, proteomic and animal model approaches are taken to more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

HUMAN MINIBRAINS GROWN FROM STEM CELLS

This project will involve CRISPR genome editing strategies combined with human stem cell derived mini-brains to investigate new neuronal factors that control development, cognitive more...

Supervisor(s): Neely, Greg (Associate Professor)

Pharmacological targeting of sphingosine 1-phosphate receptors to promote remyelination in Alzheimer’s disease and multiple sclerosis

In this project you will investigate a new molecular pathway that is required for normal myelin formation, and the therapeutic potential of targeting this pathway to promote remyeli more...

Supervisor(s): Don, Anthony (Associate Professor)

Generation of a sheep model of Batten disease using the CRISPR/Cas9 genome editing system

The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are a group of fatal neurodegenerative inherited diseases in humans and animals (http://bdsra.org/). There is no cure, but more...

Supervisor(s): Tammen, Imke (Associate Professor), Grupen, Christopher Gerald (Associate Professor)

• Roles of matrix metalloproteinases (MMPs), E-cadherin, beta-catenin, transforming growth factor (TGF-beta), epithelial & endothelial –mesenchymal transition in pathogenesis of kidney fibrosis.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

• Targeting β-catenin/Foxo to maximize anti-inflammatory and wound healing effects while preventing profibrotic effects of TGF-β as a novel treatment of chronic kidney diseases.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

CRISPR-based genome editing

The recent development of genome editing technology is perhaps the single biggest technical breakthrough in the history of life sciences, allowing for near complete control over euk more...

Supervisor(s): Neely, Greg (Associate Professor)