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Studies in Cell-Projection Pumping

Cell-projection pumping (CPP) is a mechanism we have recently discovered whereby cells pump cytoplasm between each other. We have discovered this in context of cancer, where there i more...

Supervisor(s): Zoellner, Hans (Professor)

Identifying the principles of cell growth and cell mass regulation. Development of biomedical applications based on real-time cell mass detection.

Identifying the principles of cell growth and cell mass regulation. Development of applications based on real-time cell mass detection. Development of instrumentation, sensors and m more...

Supervisor(s): Martinez Martin, David (Dr)

Develop single-cell mechanobiological methods for discovering molecular mechanisms of cardiovascular and neuronal mechanical force sensing

We are developing cutting-edge technologies for the following biomedical application: 1) define the mechanosensing functions of key protein players in the cardiovascular system such more...

Supervisor(s): Ju, Lining (Arnold) (Dr)

Reconstruct trans-regulatory networks using multi-omics profiling and data integration

A major initiative in our group is to integrate trans-omics datasets generated by a state‐of‐the‐art mass spectrometer (MS) and next-generation sequencer (NGS) from various ce more...

Supervisor(s): Yang, Pengyi (Dr)

Chemical synthesis and phenotypic validation of precision proteolysis targeted chimeras (PROTACs) for cancer and cardiovascular disease

Emerging from the interface between chemistry and biology, chemical biology has led to the establishment of several game-changing drug discovery paradigms. Among these revolutionary more...

Supervisor(s): Liu, Xuyu (Dr), Payne, Richard (Professor)

The anti-apoptotic activity of serum albumin for endothelial cells

Earlier work in my laboratory, established that serum albumin contains a cryptic protein domain that is exposed through transient intra-molecular protein movement, to bind a G-prote more...

Supervisor(s): Zoellner, Hans (Professor)

Develop point-of-care microfluidic technologies for cardiovascular and cerebrovascular diseases

We are developing a clinically useful, rapid and high throughput profiling microdevices for thrombosis and coagulation. It will be extremely useful for patients with diabetes, obesi more...

Supervisor(s): Ju, Lining (Arnold) (Dr)

Develop single-molecule and super-resolution microscopy imaging technologies in the cardiovascular disease

This project will focus on development, improvement, and application of single-molecule tracking and super-resolution imaging, such as TIRF, HiLo, PALM, STORM, Lattice Light-Sheet M more...

Supervisor(s): Ju, Lining (Arnold) (Dr)

Insulin-mediated regulation of adipocyte lipolysis

Insulin, a hormone that is released after a meal, regulates many aspects of metabolism including a process called lipolysis that involves the release of fatty acids into the circula more...

Supervisor(s): James, David (Professor)

Studies in the biophysics of dentine and dental caries

Although dental caries remains the world's most common infectious disease, current concepts of caries pathogenesis are based on microscopic methods now many decades old. Treatment w more...

Supervisor(s): Zoellner, Hans (Professor)