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Machine learning in cell identity, fate decision, and lineage prediction

Multi-omics and single-cell omics approaches are transforming our understanding of stem cell-based regeneration of tissues and organs on the individual cell level. By generating and more...

Supervisor(s): Yang, Pengyi (Dr)

Develop single-cell mechanobiological methods for discovering molecular mechanisms of cardiovascular and neuronal mechanical force sensing

We are developing cutting-edge technologies for the following biomedical application: 1) define the mechanosensing functions of key protein players in the cardiovascular system such more...

Supervisor(s): Ju, Lining (Arnold) (Dr)

Reconstruct trans-regulatory networks using multi-omics profiling and data integration

A major initiative in our group is to integrate trans-omics datasets generated by a state‐of‐the‐art mass spectrometer (MS) and next-generation sequencer (NGS) from various ce more...

Supervisor(s): Yang, Pengyi (Dr)

Chemical synthesis and phenotypic validation of precision proteolysis targeted chimeras (PROTACs) for cancer and cardiovascular disease

Emerging from the interface between chemistry and biology, chemical biology has led to the establishment of several game-changing drug discovery paradigms. Among these revolutionary more...

Supervisor(s): Liu, Xuyu (Dr), Payne, Richard (Professor)

Molecular insights into a novel mammalian oxygen-sensing pathway

Oxygen (O2) is a vital biological resource most prominently known for its role as the final electron acceptor in aerobic respiration and, as such, adequate molecular mechanisms are more...

Supervisor(s): White, Mark (Dr), Mackay, Joel (Professor)

Examining the role of ABC transporter proteins in the development of Alzheimer’s disease

Cholesterol and other lipids have been shown to be related to the development of chronic disease including Alzheimer's disease. This project will study aspects of the cellular proce more...

Supervisor(s): Gelissen, Ingrid (Dr)

Develop point-of-care microfluidic technologies for cardiovascular and cerebrovascular diseases

We are developing a clinically useful, rapid and high throughput profiling microdevices for thrombosis and coagulation. It will be extremely useful for patients with diabetes, obesi more...

Supervisor(s): Ju, Lining (Arnold) (Dr)

Insulin-mediated regulation of adipocyte lipolysis

Insulin, a hormone that is released after a meal, regulates many aspects of metabolism including a process called lipolysis that involves the release of fatty acids into the circula more...

Supervisor(s): James, David (Professor)

Defining the clinical and immunogenetic profile in antibody-associated demyelination

Masters or PhD opportunity ideally suited for a medical or neurology trainee or fellow with a commitment to building expertise in clinical and translational neuroimmunology. more...

Supervisor(s): Ramanathan, Sudarshini (Dr), Brilot-Turville, Fabienne (Dr), Dale, Russell (Professor)

Pain Phenotype Characterisation in Preclinical Models of Osteoarthritis

Osteoarthritis (OA) is the most common chronic joint disease, affecting 15% of the population and causing a significant socioeconomic burden. It is a debilitating condition characte more...

Supervisor(s): Zaki, Sanaa (Dr)