Your Search Results

Discovery and validation of new ceramide synthase inhibitors to treat metabolic disease

Ceramide synthase enzyme isoforms 1, 5, and 6, are heavily implicated as drivers of obesity, insulin resistance, and diabetes. Targeting these enzymes is expected to yield new thera more...

Supervisor(s): Don, Anthony (Associate Professor), Qi, Jacob (Dr)

Molecular insights into a novel mammalian oxygen-sensing pathway

Oxygen (O2) is a vital biological resource most prominently known for its role as the final electron acceptor in aerobic respiration and, as such, adequate molecular mechanisms are more...

Supervisor(s): White, Mark (Dr), Mackay, Joel (Professor)

‘Magic Bullet’ Cancer Drugs and Antibiotics

We are building new kinds of cancer drugs and antibiotics: molecules that change their behaviour in the presence of their biological target, being chemically activated only when the more...

Supervisor(s): Rutledge, Peter (Professor)

Facilitating treatments for neurodegenerative Parkinson’s disease

Opportunities exist to join a leading group conducting research into Parkinson's disease. Our group combines the disciplines of biochemistry, immunology, molecular biology and cell more...

Supervisor(s): Dzamko, Nicolas (Dr)

Fluorescent sensing of labile metal pools

Metals play an important role in biology, but there are only limited tools to study their functions and interactions. In this project we will develop new fluorescent tools to study more...

Supervisor(s): New, Elizabeth (Associate Professor)

Mechanism of the effect of diabetes on the inflammation and subsequent fibrosis

In our laboratory we are investigating the effects of diabetes on the inflammatory response and the initiation of fibrosis and the relationship between these changes and the develop more...

Supervisor(s): McLennan, Susan (Dr)

Understanding the Switch between Enzyme and Signaling Behaviours in Human Group IIA Secreted Phospholipase A2 by Inhibitory Intervention

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)

The global analysis of liver protein complexes during the response to intermittent fasting

In animals, short periods of nutrient deprivation, such as intermittent fasting, have been shown to provide benefits with regard to cancer risk/treatment and ageing. Our aims are to more...

Supervisor(s): Larance, Mark (Dr)

An innovative synthesis technique to fabricate nano-sized calcium phosphate particles

The project aims to develop a novel method to fabricate homogenous and non-aggregated nano-sized hydroxyapatite (HA) particles capable of delivering therapeutic nucleic acids into t more...

Supervisor(s): Rohanizadeh, Ramin (Dr)

Cell cycle control of DNA repair in lymphoid cells

PhD opportunity in an NHMRC-funded group to determine how cell cycle determines the fidelity of DNA repair in activated B cells in vivo. more...

Supervisor(s): Jolly, Chris (Dr)