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Molecular Mechanism of Insulin Resistance

Insulin resistance is a major physiological problem that is associated with an inability of insulin to regulate glucose and lipid metabolism. We now know that metabolism is central more...

Supervisor(s): James, David (Professor)

Sorting proinsulin into secretory vesicles

Reduction in glucose-stimulated mature insulin secretion and increased constitutive and regulated secretion of proinsulin are characteristics of β-cell failure. This may be due more...

Supervisor(s): Kebede, Melkam (Dr)

The primary cilia in diabetic kidney disease: targeting the cellular antennas

This project explores the role of the kidney proximal tubule cell primary cilia in diabetic nephropathy. Diabetic kidney disease is a leading cause of end stage kidney disease, requ more...

Supervisor(s): Panchapakesan, Usha (Associate Professor)

Insulin-mediated regulation of adipocyte lipolysis

Insulin, a hormone that is released after a meal, regulates many aspects of metabolism including a process called lipolysis that involves the release of fatty acids into the circula more...

Supervisor(s): James, David (Professor)

The autonomic consequences of sleep apnoea: A critical role for PACAP

We are interested to have Honours, Masters and PhD students join our team to investigate the role of PACAP and it's receptors in several models of sleep apnoea. We have exciting evi more...

Supervisor(s): Farnham, Melissa (Dr)

The nutritional geometry of non-alcoholic fatty liver disease, cardio-metabolic health and lifespan

The global epidemic of obesity and type 2 diabetes (T2D) has been linked to increased consumption of ‘western diets’ containing an abundance of processed foods rich in s more...

Supervisor(s): Simpson, Stephen (Professor), Wali, Jibran (Dr)