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Novel therapy to prevent and treat kidney fibrosis

Progressive kidney disease is a global health burden most commonly caused by diabetes and obesity, which are dramatically on the rise. In Australia, 1 in 3 adults are at risk of dev more...

Supervisor(s): Saad, Sonia (Dr), Pollock, Carol (Professor)

The interaction of chronic kidney disease and cancer

There are a range of opportunities to undertake higher degrees looking at the interaction of chronic diseases, specifically how chronic kidney disease affects cancer epidemiology. S more...

Supervisor(s): Webster, Angela (Dr)

• Roles of matrix metalloproteinases (MMPs), E-cadherin, beta-catenin, transforming growth factor (TGF-beta), epithelial & endothelial –mesenchymal transition in pathogenesis of kidney fibrosis.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

Predicting the future risk of chronic kidney disease in offspring of obese mothers with and without type 2 diabetes

Chronic kidney disease (CKD) is a major health burden driven mostly by obesity and type 2 diabetes mellitus. 1/3 of diabetic patients are at risk of CKD progression for unknown reas more...

Supervisor(s): Saad, Sonia (Dr), Pollock, Carol (Professor)

Targeting Regulatory T Cells for the Treatment of Autoimmune Renal Disease

This project will investigate the role of regulatory T cells for the treatment of autoimmunity kidney disease.    more...

Supervisor(s): Alexander, Stephen (Professor), Wang, Yuan Min (Dr)

The Cochrane Renal Group:systematic reviews of interventions and diagnostic test accuracy in Nephrology

There are a range of opportunities to undertake higher degrees looking at methodology of randomised trials, diagnostic test accuracy studies and systematic reviews. Several projects more...

Supervisor(s): Webster, Angela (Dr)

Mitochondial DNA damage, potential target to reduce the development of renal disorders induced by maternal smoking .

Smoking rates are disproportionately high in disadvantaged populations, particularly in emerging economies, and increasing in women of child bearing age. more...

Supervisor(s): Saad, Sonia (Dr)

Mechanism of the effect of diabetes on the inflammation and subsequent fibrosis

In our laboratory we are investigating the effects of diabetes on the inflammatory response and the initiation of fibrosis and the relationship between these changes and the develop more...

Supervisor(s): McLennan, Susan (Dr)

The role of miRNAs in diabetic renal interstitial fibrosis

The central aim of the project is to define the therapeutic benefit of targeting miRNAs in renal interstitial fibrosis in diabetic nephropathy. more...

Supervisor(s): Pollock, Carol (Professor), Chen, Xin-Ming (Dr)

Tubular autophagy in diabetic nephropathy

The central aim of the project is to define the role of autophagy dysfunction leading to renal tubulointerstitial fibrosis in diabetic nephropathy. more...

Supervisor(s): Pollock, Carol (Professor), Chen, Xin-Ming (Dr)