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Informatics and Bioinformatics-based Approaches to Protein-Ligand Interaction

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)

Plasmonics for Protein Attachment

Plasmonics will be used in combination with ellipsometry to investigate the attachment of biomolecules to surfaces. The structure of the attached layers will be investigated using n more...

Supervisor(s): McKenzie, David (Professor)

Structure-based drug design with Soluble Epoxide Hydrolase

Soluble Epoxide Hydrolase (sEH), and more importantly its inhibition, may form the basis of a number of therapies due to anti-inflammatory more...

Supervisor(s): Church, W Bret (Dr)

Understanding the Switch between Enzyme and Signaling Behaviours in Human Group IIA Secreted Phospholipase A2 by Inhibitory Intervention

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)

Medicinal and Pharmaceutical Chemistry — Design, Synthesis and Testing of New Anti-Bacterial Agents

This project would appeal to those with interests in pharmaceutical applications of medicinal and protein chemistry. more...

Supervisor(s): Groundwater, Paul (Professor), Church, W Bret (Dr), Hibbs, David (Dai) (Professor)

Computational investigation of high affinity ligand binding to proteins

Design of high-affinity ligands for protein targets using docking, molecular dynamics simulations and quantitative structure-activity relations. more...

Supervisor(s): Kuyucak, Serdar (Associate Professor)

Organic and Supramolecular Chemistry

The synthesis of cyclic peptides and derivatives is currently of significant interest, due to their potential applications in a range of areas spanning both chemistry and biology. N more...

Supervisor(s): Jolliffe, Katrina (Kate) (Professor)

Understanding the role of novel genes in disease

From mRNA arrays we have identified a number of ‘novel’ genes that influence tissue function. Our studies are investigating the biochemical basis for the mechanism of ac more...

Supervisor(s): Gamble, Jennifer (Professor)

Automated 3-Dimensional Biomedical Registration for Whole-body Images from Combined PET/CT Scanners - Automatic Registration for 3D Whole-body Images from Combined PET/CT Scanners

More complete utilization of complementary information from modern multi-sensor medical imaging systems to facilitate a better clinical decision making. more...

Supervisor(s): Feng, David (Professor), Wang, Xiu Ying (Dr)

Function and regulation of P-type ATPase ion pumps

The project aims to understand at the atomic level how the Na+,K+-ATPase and related ion pumps function and how they are regulated. more...

Supervisor(s): Clarke, Ron (Associate Professor)