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ASSESS THE GP GLYCOPROTEIN STRUCTURES OF EBOLA AND MARBURG VIRUS ENVELOPES, THEIR MUCIN-LIKE DOMAINS AND SITES FOR IMMUNE ATTACK

This project extends our published ebola (EBOV) gp's structures, and furthers our studies for immune targeting. Taking a holistic approach our studies aim to examine both the standa more...

Supervisor(s): Lynch, Garry (Dr)

STUDIES OF VARIABLE OR CONSERVED SURFACE PROTEIN SITES OF NEISSERIA MENINGITIDIS AS EPITOPES FOR STRAIN-SPECIFIC VACCINES OR BROAD-STRAIN (UNIVERSAL) VACCINES

The gram-negative Neisseria Meningititis (NM) remains a significant microbial problem and particularly lethal for the very young. Serogroup B strains are particularly troublesome an more...

Supervisor(s): Lynch, Garry (Dr)

Display of Viral Surface Glycoprotein on Virus like particles (VPLS) for Structure and Immune Epitope Discovery

Unanchored recombinant soluble monomers are often the proteins used in many structure analyses and immunologic testing. But in reality viral surface glycoproteins are orientated, te more...

Supervisor(s): Lynch, Garry (Dr)

Fluorescent Tools for Super-resolution Imaging

This PhD project will involve the synthesis and characterization of innovative fluorescent sensors for specific amyloid proteins implicated in neurodegenerative disorders. The devel more...

Supervisor(s): Kaur, Amandeep (Dr), Sunde, Margaret (Associate Professor)

Developing new antibiotics by targeting specific molecular interactions in bacteria

This project focuses on developing a new class of antibiotics by targeting specific molecular interactions in bacteria using a multi-disciplinary fragment-based drug design approach more...

Supervisor(s): Kwan, Ann (Dr)

Using metabolomics and other omics to guide new cancer therapies

This project will investigate cellular status and signaling in novel cancer therapies, especially new irradiation schemes in radiotherapy using metabolomics, transcriptomics and pro more...

Supervisor(s): Kwan, Ann (Dr), McKenzie, David (Professor)

Modelling plasma surface functionalisation of additively manufactured, porous, prosthetic implants

This project will develop multiphysics models of plasma surface treatment to enable the creation of prosthetic implants with controllable surface properties and long-term biostabili more...

Supervisor(s): Bilek, Marcela (Professor), Baldry, Mark (Dr)

Modelling atmospheric plasma processes for biofunctionalization in additive manufacturing

This project will develop multiphysics models of atmospheric pressure plasma systems to engineer interfaces and biofunctionalised scaffolds in 3D bioprinting.  The Applied Phys more...

Supervisor(s): Bilek, Marcela (Professor), Baldry, Mark (Dr)

Artificial Intelligence in Ion Channel Drug Discovery

Application of machine learning and artificial intelligence methods to develop models predictive of drug activity, selectivity, stability and distribution. The project will be condu more...

Supervisor(s): Balle, Thomas (Associate Professor)