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Regulating prosclerosing growth factors by incretin therapy in diabetic cardiomyopathy

Growth factors induced by diabetes contribute to tissue fibrosis and dysfunction, in conditions such as diabetic cardiomyopathy, and there is preliminary evidence that the incretins more...

Supervisor(s): Twigg, Stephen (Professor)

The Role of PPAR gamma in thyroid cancer

Differentiation therapy for thyroid cancer by targeting the fusion gene PAX8-PPARgamma. more...

Supervisor(s): Clifton-Bligh, Roderick (Dr)

Preventing rejection of transplanted organs without using immunosuppressive drugs

The project aims to identify molecular pathways to prevent rejection of transplanted organs in animal models and to apply these findings to clinical transplantation. more...

Supervisor(s): Bishop, Alex (Dr)

Clinical utility of MS molecular phenotypes of MS

My group at the Centre for Immunology aims to translate immunogenetic findings from discovery to clinical practice. We have used genome wide association studies to identify genetic more...

Supervisor(s): Booth, David (Associate Professor)

Significance of Osteopontin and its splice variants in alcoholic liver disease

Alcohol induced Opn and Opn isoforms play a role in the progression of alcoholic liver injury mediated via integrin and non-integrin receptor binding. more...

Supervisor(s): Seth, Devanshi (Dr)

The transformation of normal melanocytes into melanoma

This project investigates the role of the oncogenes Ras and Braf and the tumour suppressors p16INK4a, p14ARF, p53 and PTEN in the malignant transformation of melanocytes. more...

Supervisor(s): Kefford, Richard (Professor)

Novel therapies for treating progressive chronic kidney disease

The use of DNA vaccination and regulatory cells to treat progressive kidney disease. more...

Supervisor(s): Harris, David (Professor)

Proteomic Mapping and Molecular Modelling of Avian H5N1 Influenza Antigen Epitopes Targeted by Human Antibodies

In studying Avian H5N1 Influenza specific Antibodies within Humans the aim is to clearly and definitively identify the respective viral proteins and epitopes targeted by neutralizin more...

Supervisor(s): Lynch, Garry (Dr)

Investigation of virulence genes upregulated in coinfection between P. aeruginosa and other species

Identify the set of genes diffrentially expressed when P. aeruginosa is grown in coculture with three other infecting species. Select genes with virulence/persistence characteristic more...

Supervisor(s): Manos, Jim (Dr)

A Novel Approach of Inhibiting Pancreatic Cancer Metastasis via Targeting Tumour Micro-Environment Induced Autophagy

Targeting autophagy and metastasis in pancreatic cancer via NDRG1 Pancreatic Cancer (PC) is highly metastatic with the highest mortality of all cancers (~93%). The pancreatic tu more...

Supervisor(s): Sahni, Sumit (Dr)