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Sleep and Cancer: The role of intermittent hypoxia

Background: Recent epidemiological studies have shown that patients with obstructive sleep apnoea (OSA) have higher rates of cancer and cancer mortality however the underlying mecha more...

Supervisor(s): Cook, Kristina (Dr), Cistulli, Peter (Professor)

Control of complement cascade by labile disulphide bonds

The complement system is a key component of innate immunity that offers sophisticated protection against threats to the host organism. Complement is also an important component of t more...

Supervisor(s): Chiu, Joyce (Dr)

HUMAN MINIBRAINS GROWN FROM STEM CELLS

This project will involve CRISPR genome editing strategies combined with human stem cell derived mini-brains to investigate new neuronal factors that control development, cognitive more...

Supervisor(s): Neely, Greg (Professor)

Analysis of Human Responses to Intermittent Fasting

Analysis of human samples generated from intervention-based clinical trials of intermittent fasting. Our aim is to understand the molecular mechanisms mediating the beneficial pheno more...

Supervisor(s): Larance, Mark (Dr)

Regulation of stem cell behaviour using functional biomolecules

Investigate and develop new ways of manipulating different aspects of stem cell behaviour.  This knowledge paves the way towards understanding their fundamental biology and cre more...

Supervisor(s): Yeo, Giselle (Dr)

Discovery and validation of new ceramide synthase inhibitors to treat metabolic disease

Ceramide synthase enzyme isoforms 1, 5, and 6, are heavily implicated as drivers of obesity, insulin resistance, and diabetes. Targeting these enzymes is expected to yield new thera more...

Supervisor(s): Don, Anthony (Associate Professor), Qi, Jacob (Dr)

Viral Commandeering of Cellular Oncogenic Signalling Pathways

Cell-to-cell spread of caccinia virus infection induces dramatic rearrangements to cell morphology and alterations to cell behaviour.  This project will study the role of host more...

Supervisor(s): Newsome, Timothy (Dr)

Maternal autoimmunity increases risk of neurodevelopmental problems in offspring.

Maternal autoimmunity is a recognised risk factor for autism and other neurodevelopmental and psychiatric disorders in the offspring. It is well established in humans and animal mod more...

Supervisor(s): Dale, Russell (Professor), Hofer, Markus (Dr)

Pharmacological targeting of sphingosine 1-phosphate receptors to promote remyelination in Alzheimer’s disease and multiple sclerosis

In this project you will investigate a new molecular pathway that is required for normal myelin formation, and the therapeutic potential of targeting this pathway to promote remyeli more...

Supervisor(s): Don, Anthony (Associate Professor)

Utility of Cerebrospinal fluid proteomics to define molecular mechanisms in brain disease of childhood.

Brain diseases of childhood are very common and result in significant disability, and cost to the nation. Common diseases include epilepsy, cerebral palsy, autism and mental health more...

Supervisor(s): Dale, Russell (Professor)