Your Search Results

Discovery and validation of new ceramide synthase inhibitors to treat metabolic disease

Ceramide synthase enzyme isoforms 1, 5, and 6, are heavily implicated as drivers of obesity, insulin resistance, and diabetes. Targeting these enzymes is expected to yield new thera more...

Supervisor(s): Don, Anthony (Associate Professor), Qi, Jacob (Dr)

Structure-based drug design with Kynurenine Aminotransferase-2

Human kynurenine amino transferase-2 (KAT-2) forms the basis of a structure-based drug design study with implications for schizophrenia and gender differences.  The various asp more...

Supervisor(s): Church, W Bret (Dr)

Chemical synthesis and phenotypic validation of precision proteolysis targeted chimeras (PROTACs) for cancer and cardiovascular disease

Emerging from the interface between chemistry and biology, chemical biology has led to the establishment of several game-changing drug discovery paradigms. Among these revolutionary more...

Supervisor(s): Liu, Xuyu (Dr), Payne, Richard (Professor)

Developing new antibiotics by targeting specific molecular interactions in bacteria

This project focuses on developing a new class of antibiotics by targeting specific molecular interactions in bacteria using a multi-disciplinary fragment-based drug design approach more...

Supervisor(s): Kwan, Ann (Dr)

The anti-apoptotic activity of serum albumin for endothelial cells

Earlier work in my laboratory, established that serum albumin contains a cryptic protein domain that is exposed through transient intra-molecular protein movement, to bind a G-prote more...

Supervisor(s): Zoellner, Hans (Professor)

Facilitating treatments for neurodegenerative Parkinson’s disease

Opportunities exist to join a leading group conducting research into Parkinson's disease. Our group combines the disciplines of biochemistry, immunology, molecular biology and cell more...

Supervisor(s): Dzamko, Nicolas (Dr)

Organic chemistry: Anti-cancer peptide therapeutics

Visit our group website for the latest information - laugroup.net more...

Supervisor(s): Lau, Yu Heng (Dr)

STUDIES OF VARIABLE OR CONSERVED SURFACE PROTEIN SITES OF NEISSERIA MENINGITIDIS AS EPITOPES FOR STRAIN-SPECIFIC VACCINES OR BROAD-STRAIN (UNIVERSAL) VACCINES

The gram-negative Neisseria Meningititis (NM) remains a significant microbial problem and particularly lethal for the very young. Serogroup B strains are particularly troublesome an more...

Supervisor(s): Lynch, Garry (Dr)

Pain Phenotype Characterisation in Preclinical Models of Osteoarthritis

Osteoarthritis (OA) is the most common chronic joint disease, affecting 15% of the population and causing a significant socioeconomic burden. It is a debilitating condition characte more...

Supervisor(s): Zaki, Sanaa (Dr)

Pharmacological targeting of sphingosine 1-phosphate receptors to promote remyelination in Alzheimer’s disease and multiple sclerosis

In this project you will investigate a new molecular pathway that is required for normal myelin formation, and the therapeutic potential of targeting this pathway to promote remyeli more...

Supervisor(s): Don, Anthony (Associate Professor)