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Role of Protein Phosphorylation in Cellular Function

Using advances in mass spectrometry-based proteomics this project aims to uncover how phosphorylation affects the function of proteins and cells in both healthy and diseased states. more...

Supervisor(s): James, David (Professor)

Characterising changes in a proteome of islets and islet cell types during progression to type 2 diabetes

Characterizing changes in a proteome through pathogenesis of diseases can provide unparalleled insights into the mechanisms underpinning disease. In this project, using flow cytomet more...

Supervisor(s): Kebede, Melkam (Dr)

Uncovering the source of CO2 that’s respired when dry soil is rewet

Soil respiration is one of the largest components of the global C cycle, but also one of the hardest to model. A key aspect of this difficulty is that we do not have a good mechanis more...

Supervisor(s): Warren, Charles (Associate Professor)

CHARACTERISATION OF ERUSIOLIN - A NEW PEPTIDE HORMONE

In this project we aim to characterise the function of a new gut-derived peptide we have discovered in human plasma, named erusiolin, which we hypothesise plays a role in appetite r more...

Supervisor(s): Larance, Mark (Dr)

Sorting proinsulin into secretory vesicles

Reduction in glucose-stimulated mature insulin secretion and increased constitutive and regulated secretion of proinsulin are characteristics of β-cell failure. This may be due more...

Supervisor(s): Kebede, Melkam (Dr)

Characterising insulin secretory granules as a function of age

In β-cells, insulin is stored in secretory granules (SGs). Upon stimulation, these SGs deliver insulin to the bloodstream. It is known that SGs exist in two functionally distin more...

Supervisor(s): Kebede, Melkam (Dr)

Molecular insights into a novel mammalian oxygen-sensing pathway

Oxygen (O2) is a vital biological resource most prominently known for its role as the final electron acceptor in aerobic respiration and, as such, adequate molecular mechanisms are more...

Supervisor(s): White, Mark (Dr), Mackay, Joel (Professor)

Do co-occurring plants avoid competing for N?

All plants require nitrogen, so how can species co-exist if they're competing for the same limiting resource? This project will examine the hypothesis that plants avoid competing fo more...

Supervisor(s): Warren, Charles (Associate Professor)

Studies in the biophysics of dentine and dental caries

Although dental caries remains the world's most common infectious disease, current concepts of caries pathogenesis are based on microscopic methods now many decades old. Treatment w more...

Supervisor(s): Zoellner, Hans (Professor)

Facilitating treatments for neurodegenerative Parkinson’s disease

Opportunities exist to join a leading group conducting research into Parkinson's disease. Our group combines the disciplines of biochemistry, immunology, molecular biology and cell more...

Supervisor(s): Dzamko, Nicolas (Dr)