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Cold Drawing of Polycaprolactone Fibres

This project will focus on fine tuning of the PCL fibres morphology through cold drawing. The effect of different cold-drawing regimes resulting in different relative elongations of more...

Supervisor(s): Rukhlenko, Ivan (Dr), Fleming, Simon (Professor), Farajikhah, Syamak (Dr)

Dental robotics

Robotic dental surgery offers significant clinical advantages, but has not yet been developed. We are exploring development of dental robotics in collaboration with the Faculty of E more...

Supervisor(s): Zoellner, Hans (Professor)

Modelling plasma surface functionalisation of additively manufactured, porous, prosthetic implants

This project will develop multiphysics models of plasma surface treatment to enable the creation of prosthetic implants with controllable surface properties and long-term biostabili more...

Supervisor(s): Bilek, Marcela (Professor), Baldry, Mark (Dr)

Studies in the biophysics of dentine and dental caries

Although dental caries remains the world's most common infectious disease, current concepts of caries pathogenesis are based on microscopic methods now many decades old. Treatment w more...

Supervisor(s): Zoellner, Hans (Professor)

PRECLINICAL AND CLINICAL DEVELOPMENT OF NOVEL BONE-BINDING ANTIMICROBIALS

Our team has spent several years developing and testing new a new class of drugs termed bone-binding antimicrobials (BBAs). Our lead compound (BBA-1) has been shown to have antimicr more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Little, David (Professor)

UNDERSTANDING GENETIC VARIATIONS IN BONE

Functional genomics is a field that is undergoing major changes in practice due to the accessibility of gene editing technologies. Our team has developed methods for gene editing in more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Munns, Craig (Associate Professor)

GENE THERAPY FOR GENETIC BONE DISEASES

Gene therapy is becoming a practical approach to treat severe genetic conditions and in recent years conditions such as Spinal Muscular Atrophy (SMA) have been success stories. Our more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Munns, Craig (Associate Professor)

The anti-apoptotic activity of serum albumin for endothelial cells

Earlier work in my laboratory, established that serum albumin contains a cryptic protein domain that is exposed through transient intra-molecular protein movement, to bind a G-prote more...

Supervisor(s): Zoellner, Hans (Professor)

Studies in Cell-Projection Pumping

Cell-projection pumping (CPP) is a mechanism we have recently discovered whereby cells pump cytoplasm between each other. We have discovered this in context of cancer, where there i more...

Supervisor(s): Zoellner, Hans (Professor)