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Impact of chronic inflammation on bowel and sexual function

Inflammatory bowel diseases (IBD) is difficult to treat and secondary pathological outcome can include decreased fertility. Also, many of the available treatments cause unwanted se more...

Supervisor(s): Witting, Paul (Dr)

Control of complement cascade by labile disulphide bonds

The complement system is a key component of innate immunity that offers sophisticated protection against threats to the host organism. Complement is also an important component of t more...

Supervisor(s): Chiu, Joyce (Dr)

Maternal autoimmunity increases risk of neurodevelopmental problems in offspring.

Maternal autoimmunity is a recognised risk factor for autism and other neurodevelopmental and psychiatric disorders in the offspring. It is well established in humans and animal mod more...

Supervisor(s): Dale, Russell (Professor), Hofer, Markus (Dr)

Maternal Oral Health and Pregnancy Outcomes

Inflammatory processes in the oral cavity can have a systemic affect as has been shown with atherosclerosis. These systemic affects are likely to influence the immune and metabolic more...

Supervisor(s): Eberhard, Joerg (Professor)

Pregnancy and Maternal Oral Health

Background: Recently, a number of studies have shown that poor oral health may impact on general health. Periodontal diseases have been identified as an independent risk factor for more...

Supervisor(s): Nanan, Ralph (Professor)

Factors affecting oral health in cerebral palsy patients: dental caries experience, microbiome and oral health related quality of life (OHRQoL)

Cerebral palsy (CP) is a set of nonprogressive neuromuscular disorders caused by defects in the developing fetal brain. Children with Cerebral Palsy are often have physical, coordin more...

Supervisor(s): Akhter, Rahena (Dr)

Utility of Cerebrospinal fluid proteomics to define molecular mechanisms in brain disease of childhood.

Brain diseases of childhood are very common and result in significant disability, and cost to the nation. Common diseases include epilepsy, cerebral palsy, autism and mental health more...

Supervisor(s): Dale, Russell (Professor)

Pharmacological targeting of sphingosine 1-phosphate receptors to promote remyelination in Alzheimer’s disease and multiple sclerosis

In this project you will investigate a new molecular pathway that is required for normal myelin formation, and the therapeutic potential of targeting this pathway to promote remyeli more...

Supervisor(s): Don, Anthony (Associate Professor)

• Roles of matrix metalloproteinases (MMPs), E-cadherin, beta-catenin, transforming growth factor (TGF-beta), epithelial & endothelial –mesenchymal transition in pathogenesis of kidney fibrosis.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

• Targeting β-catenin/Foxo to maximize anti-inflammatory and wound healing effects while preventing profibrotic effects of TGF-β as a novel treatment of chronic kidney diseases.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)