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Dietary effects to the local immune response and the initiation and propagation of diabetes and cardiovascular disease in mice

Background: Longitudinal studies have demonstrated a two-¬way relationship between diabetes and the local inflammatory host response, e.g. periodontitis, with more severe period more...

Supervisor(s): Eberhard, Joerg (Professor)

Influencing anti-inflammatory functions of monocytes by targeting the haemoglobin scavenger receptor CD163: possible role in the development of diabetes complications

This project addresses the problem of how causes of diabetes complications, specifically the effect of diabetes on the regulation of one of these anti-inflammatory cell surface prot more...

Supervisor(s): Min, Danqing (Dr), McLennan, Susan (Dr), Twigg, Stephen (Professor)

Maternal autoimmunity increases risk of neurodevelopmental problems in offspring.

Maternal autoimmunity is a recognised risk factor for autism and other neurodevelopmental and psychiatric disorders in the offspring. It is well established in humans and animal mod more...

Supervisor(s): Dale, Russell (Professor), Hofer, Markus (Dr)

Maternal Oral Health and Pregnancy Outcomes

Inflammatory processes in the oral cavity can have a systemic affect as has been shown with atherosclerosis. These systemic affects are likely to influence the immune and metabolic more...

Supervisor(s): Eberhard, Joerg (Professor)

Pregnancy and Maternal Oral Health

Background: Recently, a number of studies have shown that poor oral health may impact on general health. Periodontal diseases have been identified as an independent risk factor for more...

Supervisor(s): Nanan, Ralph (Professor)

Computational Modeling of Immune Cell Chemotaxis and Swarming

 Using computational simulation to form and evaluate hypotheses concerning the factors that drive immune cell motility, such as neutrophil swarming, during inflammation. more...

Supervisor(s): Read, Mark (Dr)

Factors affecting oral health in cerebral palsy patients: dental caries experience, microbiome and oral health related quality of life (OHRQoL)

Cerebral palsy (CP) is a set of nonprogressive neuromuscular disorders caused by defects in the developing fetal brain. Children with Cerebral Palsy are often have physical, coordin more...

Supervisor(s): Akhter, Rahena (Dr)

Pharmacological targeting of sphingosine 1-phosphate receptors to promote remyelination in Alzheimer’s disease and multiple sclerosis

In this project you will investigate a new molecular pathway that is required for normal myelin formation, and the therapeutic potential of targeting this pathway to promote remyeli more...

Supervisor(s): Don, Anthony (Associate Professor)

• Roles of matrix metalloproteinases (MMPs), E-cadherin, beta-catenin, transforming growth factor (TGF-beta), epithelial & endothelial –mesenchymal transition in pathogenesis of kidney fibrosis.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

• Targeting β-catenin/Foxo to maximize anti-inflammatory and wound healing effects while preventing profibrotic effects of TGF-β as a novel treatment of chronic kidney diseases.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)