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Molecular insights into a novel mammalian oxygen-sensing pathway

Oxygen (O2) is a vital biological resource most prominently known for its role as the final electron acceptor in aerobic respiration and, as such, adequate molecular mechanisms are more...

Supervisor(s): White, Mark (Dr), Mackay, Joel (Professor)

Design and synthesis of selective anion receptors to facilitate transmembrane anion transport in epithelial cells

CF is a recessive genetic condition that results from the dysregulation of anion transport through the cystic fibrosis transmembrane regulator anion channel in epithelial cell membr more...

Supervisor(s): Gale, Philip (Professor)

Transformersomes: shape-shifting polymer nanostructures

Synthetic polymers can self-assemble into an impressive spectrum of well-defined nanoscale architectures that behave in intriguing ways, from catalysing chemical reactions to intera more...

Supervisor(s): Roberts, Derrick (Dr)

THE PATHOGENIC AND PROTECTIVE EFFECTS OF MICROGLIA IN CEREBRAL CYTOKINOPATHIES

Microglia are the primary immune cells of the brain and have the potential to both protect and contribute to neurological disease. Explore the molecular mechanisms that microglia us more...

Supervisor(s): Hofer, Markus (Dr)

Display of Viral Surface Glycoprotein on Virus like particles (VPLS) for Structure and Immune Epitope Discovery

Unanchored recombinant soluble monomers are often the proteins used in many structure analyses and immunologic testing. But in reality viral surface glycoproteins are orientated, te more...

Supervisor(s): Lynch, Garry (Dr)

EFFECTS OF TYPE I INTERFERONS IN CHRONIC VIRAL INFECTIONS

When type I interferon signalling is impaired, infection with lymphocytic choriomeningitis virus results in chronic infection and dysfunctional CD8+ T cell function. Investigate how more...

Supervisor(s): Hofer, Markus (Dr)

Organometallics and Catalysis

The projects will focus on novel monometallic and multimetallic transition metal catalysts as well as new methodologies for catalysis and developing surface supported catalysts. The more...

Supervisor(s): Messerle, Barbara (Professor)

STUDIES OF VARIABLE OR CONSERVED SURFACE PROTEIN SITES OF NEISSERIA MENINGITIDIS AS EPITOPES FOR STRAIN-SPECIFIC VACCINES OR BROAD-STRAIN (UNIVERSAL) VACCINES

The gram-negative Neisseria Meningititis (NM) remains a significant microbial problem and particularly lethal for the very young. Serogroup B strains are particularly troublesome an more...

Supervisor(s): Lynch, Garry (Dr)

TARGETING THE BRAIN VASCULATURE AS A TREATMENT FOR CEREBRAL TYPE I INTERFERONOPATHIES

Abnormal blood vessels are feature of cerebral type I interferonopathies. Discover how the endothelial cells that line the brain’s blood vessels contribute to disease in patie more...

Supervisor(s): Hofer, Markus (Dr)

HOW DIFFERENT CELL TYPES OF THE BRAIN CONTRIBUTE TO CEREBRAL CYTOKINOPATHIES

The brain consists of a large number of different cell types, including neurons, astrocytes, oligodendrocytes, microglia and endothelial cells. Discover how these different cell typ more...

Supervisor(s): Hofer, Markus (Dr)