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Gene editing of stem cells or cancer to develop new stem cell therapies to treat human disease

This project involves the use of human stem cells and CRISPR genome editing to study basic signalling pathways controlling stem cell differentiation and/or cancer. A compliment more...

Supervisor(s): Neely, Greg (Associate Professor)

Harmful or beneficial aspects of oral facial tissue and environment to the cardiac regeneration: Periodontitis may worsen the outcome of cardiac function after injury whilst the orofacial stem cells may augment their regenerative capacity.

A rodent model of myocardial injury will be used to investigate cardiac function. We will investigate the detrimental effect of a chronic inflammatory disease (periodontitis) on car more...

Supervisor(s): Xaymardan, Munira (Dr), Eberhard, Joerg (Professor)

Machine learning in cell identity, fate decision, and lineage prediction

Multi-omics and single-cell omics approaches are transforming our understanding of stem cell-based regeneration of tissues and organs on the individual cell level. By generating and more...

Supervisor(s): Yang, Pengyi (Dr)

The anti-apoptotic activity of serum albumin for endothelial cells

Earlier work in my laboratory, established that serum albumin contains a cryptic protein domain that is exposed through transient intra-molecular protein movement, to bind a G-prote more...

Supervisor(s): Zoellner, Hans (Professor)

Studies in Cell-Projection Pumping

Cell-projection pumping (CPP) is a mechanism we have recently discovered whereby cells pump cytoplasm between each other. We have discovered this in context of cancer, where there i more...

Supervisor(s): Zoellner, Hans (Professor)

Conserved Regulatory Genes in Neurodevelopment

The present project aims to utilize the promising combination of 3D organoid technology and CRISPR genome editing, which will allow us to examine the roles of several conserved gene more...

Supervisor(s): Neely, Greg (Associate Professor)

Riboflavin for corneal collagen cross-linking

Most of the clinical research evaluating outcomes of treatment for keratoconus is limited mainly owing to two reasons: 1. low sample size, and 2. short follow-up period. The Save Si more...

Supervisor(s): Watson, Stephanie (Professor), Kandel, Himal (Dr)

Studies in the biophysics of dentine and dental caries

Although dental caries remains the world's most common infectious disease, current concepts of caries pathogenesis are based on microscopic methods now many decades old. Treatment w more...

Supervisor(s): Zoellner, Hans (Professor)

Dental robotics

Robotic dental surgery offers significant clinical advantages, but has not yet been developed. We are exploring development of dental robotics in collaboration with the Faculty of E more...

Supervisor(s): Zoellner, Hans (Professor)