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Computational characterisation of trans-regulatory cell systems

This project aims provide enabling computational and statistical methods for characterising trans-regulatory networks in cell systems. The goal is to discover regulatory networks th more...

Supervisor(s): Yang, Pengyi (Dr)

Neuromorphic AI

This project involves complex systems modelling of neuromorphic atomic switch networks to emulate emergent brain-like features of adaptive, deep-learning for application to Artifici more...

Supervisor(s): Kuncic, Zdenka (Professor)

Molecular insights into a novel mammalian oxygen-sensing pathway

Oxygen (O2) is a vital biological resource most prominently known for its role as the final electron acceptor in aerobic respiration and, as such, adequate molecular mechanisms are more...

Supervisor(s): White, Mark (Dr), Mackay, Joel (Professor)

HUMAN MINIBRAINS GROWN FROM STEM CELLS

This project will involve CRISPR genome editing strategies combined with human stem cell derived mini-brains to investigate new neuronal factors that control development, cognitive more...

Supervisor(s): Neely, Greg (Professor)

Pharmacological targeting of sphingosine 1-phosphate receptors to promote remyelination in Alzheimer’s disease and multiple sclerosis

In this project you will investigate a new molecular pathway that is required for normal myelin formation, and the therapeutic potential of targeting this pathway to promote remyeli more...

Supervisor(s): Don, Anthony (Associate Professor)

Discovery and validation of new ceramide synthase inhibitors to treat metabolic disease

Ceramide synthase enzyme isoforms 1, 5, and 6, are heavily implicated as drivers of obesity, insulin resistance, and diabetes. Targeting these enzymes is expected to yield new thera more...

Supervisor(s): Don, Anthony (Associate Professor), Qi, Jacob (Dr)

Gene editing of stem cells or cancer to develop new stem cell therapies to treat human disease

This project involves the use of human stem cells and CRISPR genome editing to study basic signalling pathways controlling stem cell differentiation and/or cancer. A compliment more...

Supervisor(s): Neely, Greg (Professor)

Tracking antibiotic resistance genes and mobile genetic elements in the environment

Antibiotic resistance is a massive problem for medicine, and thus much effort is being put into understanding the genetic basis of how bacteria evolve so quickly to become resistant more...

Supervisor(s): Coleman, Nicholas (Associate Professor)

A sensor driven approach to assessing health in honey bee colonies

This project aims to optimise honey bee colony health by developing low-cost sensor arrays. The supervisory team for this project also includes Dr Ash Rahman (Data61) and Dr Jo more...

Supervisor(s): Latty, Tanya (Dr)

CRISPR-based genome editing

The recent development of genome editing technology is perhaps the single biggest technical breakthrough in the history of life sciences, allowing for near complete control over euk more...

Supervisor(s): Neely, Greg (Professor)