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Diabetes and beta-cell gene expression

Diabetes develops when the insulin secreting beta-cells in the pancreas can no longer release enough insulin to control blood glucose concentrations. This often occurs in the settin more...

Supervisor(s): Gunton, Jenny (Professor)

Oral health care and diabetes – assessing the 45 and up study with oral health data from PBS/MBS and hospital admission data

A two-way relationship has been proven to exist between diabetes and periodontal disease. Linking epidemiological data from the 45 and up study to dental treatment and appointment d more...

Supervisor(s): Eberhard, Joerg (Professor)

Frequency and severity of periodontal disease in Australians with Type 2 diabetes mellitus: Building representative epidemiological data and validation of a screening tool for non-dental personnel.

Oral health and Type II diabetes encompasses many health complications that can have a profound impact on the patient's quality of life. The relationship between Type II Diabetes an more...

Supervisor(s): Eberhard, Joerg (Professor)

Treating obesity by activating beige and brown fat; human transplant studies

Obesity occurs when energy intake exceeds energy expenditure. Current treatments for obesity are largely ineffective, and two-thirds of Australian adults are now overweight or obese more...

Supervisor(s): Gunton, Jenny (Professor)

Novel therapy to prevent and treat kidney fibrosis

Progressive kidney disease is a global health burden most commonly caused by diabetes and obesity, which are dramatically on the rise. In Australia, 1 in 3 adults are at risk of dev more...

Supervisor(s): Saad, Sonia (Dr), Pollock, Carol (Professor)

• Roles of matrix metalloproteinases (MMPs), E-cadherin, beta-catenin, transforming growth factor (TGF-beta), epithelial & endothelial –mesenchymal transition in pathogenesis of kidney fibrosis.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

• Targeting β-catenin/Foxo to maximize anti-inflammatory and wound healing effects while preventing profibrotic effects of TGF-β as a novel treatment of chronic kidney diseases.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

Muscle wasting and vitamin D

Muscle wasting and weakness are common, and associate with an increased risk of death. Therapies to improve muscle function are very limited, and understanding of the transcriptiona more...

Supervisor(s): Gunton, Jenny (Professor)

What is the association between musculoskeletal conditions and cardio metabolic disease in the Australian population?

This research project aims to investigate the association between musculoskeletal conditions and cardio metabolic diseases and its relationship with physical activity participation. more...

Supervisor(s): Hiller, Claire (Dr), Harmer, Alison (Dr), Beckenkamp, Paula (Dr)

The role of key driver genes in the pathogenesis of acute renal allograft rejection

This is a PhD project. The successful applicant will be top up scholarship. This study will lead to publish high quality of papers and apply a new NHMRC project grant. more...

Supervisor(s): O'Connell, Philip (Professor), Hu, Min (Dr)