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Tracking antibiotic resistance genes and mobile genetic elements in the environment

Antibiotic resistance is a massive problem for medicine, and thus much effort is being put into understanding the genetic basis of how bacteria evolve so quickly to become resistant more...

Supervisor(s): Coleman, Nicholas (Associate Professor)

A New Therapeutic Strategy to Overcome Multidrug Resistance by Exploiting Drug-Transporters to Target Untreatable Cancers

We recently have discovered a frontier strategy for overcoming drug resistance mediated by P-glycoprotein (Pgp) in the lysosome. Identifying new targets for resistant cancers are cr more...

Supervisor(s): Jansson, Patric (Dr)

Discovery and validation of new ceramide synthase inhibitors to treat metabolic disease

Ceramide synthase enzyme isoforms 1, 5, and 6, are heavily implicated as drivers of obesity, insulin resistance, and diabetes. Targeting these enzymes is expected to yield new thera more...

Supervisor(s): Don, Anthony (Associate Professor), Qi, Jacob (Dr)

Diabetes and beta-cell gene expression

Diabetes develops when the insulin secreting beta-cells in the pancreas can no longer release enough insulin to control blood glucose concentrations. This often occurs in the settin more...

Supervisor(s): Gunton, Jenny (Professor)

Genomics of rust pathogens

The cereal rust pathogens are among the most damaging of all plant pathogens. Using genome sequencing and transcriptome analysis, this project will examine how rust pathogens establ more...

Supervisor(s): Park, Robert (Professor)

Characterising insulin secretory granules as a function of age

In β-cells, insulin is stored in secretory granules (SGs). Upon stimulation, these SGs deliver insulin to the bloodstream. It is known that SGs exist in two functionally distin more...

Supervisor(s): Kebede, Melkam (Dr)

Characterising changes in a proteome of islets and islet cell types during progression to type 2 diabetes

Characterizing changes in a proteome through pathogenesis of diseases can provide unparalleled insights into the mechanisms underpinning disease. In this project, using flow cytomet more...

Supervisor(s): Kebede, Melkam (Dr)

Mycoviruses of rust pathogens

Most if not all rust species that have been studied to date carry mycovisues. The role of these hyperparasites is not understood at all. The project will undertake sequencing of myc more...

Supervisor(s): Park, Robert (Professor)

Phylogenetics of rust pathogens

There are about 7,000 rust species, some of which are among the most damaging of all plant pathogens. Using genome sequencing and transcriptome analysis, this project will contribut more...

Supervisor(s): Park, Robert (Professor)

Reorganising for Outcomes: Credentialling in Infection Control for Improved Quality Outcomes

This study will examine the effect of organising infection control services for outcomes. Specifically, it will explore the effect of formal credentialing of infection control pract more...

Supervisor(s): Shaban, Ramon (Professor)