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EFFECTS OF TYPE I INTERFERONS IN CHRONIC VIRAL INFECTIONS

When type I interferon signalling is impaired, infection with lymphocytic choriomeningitis virus results in chronic infection and dysfunctional CD8+ T cell function. Investigate how more...

Supervisor(s): Hofer, Markus (Dr)

The primary cilia in diabetic kidney disease: targeting the cellular antennas

This project explores the role of the kidney proximal tubule cell primary cilia in diabetic nephropathy. Diabetic kidney disease is a leading cause of end stage kidney disease, requ more...

Supervisor(s): Panchapakesan, Usha (Associate Professor)

Machine learning in cell identity, fate decision, and lineage prediction

Multi-omics and single-cell omics approaches are transforming our understanding of stem cell-based regeneration of tissues and organs on the individual cell level. By generating and more...

Supervisor(s): Yang, Pengyi (Dr)

Chemical synthesis and phenotypic validation of precision proteolysis targeted chimeras (PROTACs) for cancer and cardiovascular disease

Emerging from the interface between chemistry and biology, chemical biology has led to the establishment of several game-changing drug discovery paradigms. Among these revolutionary more...

Supervisor(s): Liu, Xuyu (Dr), Payne, Richard (Professor)

Modelling plasma surface functionalisation of additively manufactured, porous, prosthetic implants

This project will develop multiphysics models of plasma surface treatment to enable the creation of prosthetic implants with controllable surface properties and long-term biostabili more...

Supervisor(s): Bilek, Marcela (Professor), Baldry, Mark (Dr)