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Gene editing of stem cells or cancer to develop new stem cell therapies to treat human disease

This project involves the use of human stem cells and CRISPR genome editing to study basic signalling pathways controlling stem cell differentiation and/or cancer. A compliment more...

Supervisor(s): Neely, Greg (Professor)

Control of immune cell activity via a redox switch in integrin

Our immune system protects us from invasion of pathogens and toxic materials. Immune cells such as monocytes and neutrophils circulate in the blood to monitor foreign materials and more...

Supervisor(s): Chiu, Joyce (Dr)

Imaging atherogenesis in a zebrafish model

This project will characterise immune cell dynamics during atherogenesis by live imaging, and investigate the importance of vascular remodelling and leakage in fuelling atheroma pat more...

Supervisor(s): Oehlers, Stefan (Dr), Britton, Warwick J (Professor)

Control of complement cascade by labile disulphide bonds

The complement system is a key component of innate immunity that offers sophisticated protection against threats to the host organism. Complement is also an important component of t more...

Supervisor(s): Chiu, Joyce (Dr)

Design and synthesis of selective anion receptors to facilitate transmembrane anion transport in epithelial cells

CF is a recessive genetic condition that results from the dysregulation of anion transport through the cystic fibrosis transmembrane regulator anion channel in epithelial cell membr more...

Supervisor(s): Gale, Philip (Professor)

Vascular dysfunction in mycobacterial pathogenesis

This project will investigate the importance of vascular remodelling and leakage in fuelling tuberculosis infection more...

Supervisor(s): Oehlers, Stefan (Dr), Britton, Warwick J (Professor)

Mechanosensation in human erythrocytes: NMR and microscopy studies

We/you will explore the mechanistic basis of the autonomous movement of the plasma membrane of red blood cells, so called membrane flickering. Also, the molecular processes that und more...

Supervisor(s): Kuchel, Philip (Emeritus Professor)

ASSESS THE GP GLYCOPROTEIN STRUCTURES OF EBOLA AND MARBURG VIRUS ENVELOPES, THEIR MUCIN-LIKE DOMAINS AND SITES FOR IMMUNE ATTACK

This project extends our published ebola (EBOV) gp's structures, and furthers our studies for immune targeting. Taking a holistic approach our studies aim to examine both the standa more...

Supervisor(s): Lynch, Garry (Dr)

Display of Viral Surface Glycoprotein on Virus like particles (VPLS) for Structure and Immune Epitope Discovery

Unanchored recombinant soluble monomers are often the proteins used in many structure analyses and immunologic testing. But in reality viral surface glycoproteins are orientated, te more...

Supervisor(s): Lynch, Garry (Dr)

STUDIES OF VARIABLE OR CONSERVED SURFACE PROTEIN SITES OF NEISSERIA MENINGITIDIS AS EPITOPES FOR STRAIN-SPECIFIC VACCINES OR BROAD-STRAIN (UNIVERSAL) VACCINES

The gram-negative Neisseria Meningititis (NM) remains a significant microbial problem and particularly lethal for the very young. Serogroup B strains are particularly troublesome an more...

Supervisor(s): Lynch, Garry (Dr)