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Characterising changes in a proteome of islets and islet cell types during progression to type 2 diabetes

Characterizing changes in a proteome through pathogenesis of diseases can provide unparalleled insights into the mechanisms underpinning disease. In this project, using flow cytomet more...

Supervisor(s): Kebede, Melkam (Dr)

Characterising insulin secretory granules as a function of age

In β-cells, insulin is stored in secretory granules (SGs). Upon stimulation, these SGs deliver insulin to the bloodstream. It is known that SGs exist in two functionally distin more...

Supervisor(s): Kebede, Melkam (Dr)

The role of redox in signalling: assessing the requirement of reactive oxygen species in signal transduction

Define the role of ROS in insulin signal transduction and explore how loss of control of this process causes diseases such as diabetes and cancer more...

Supervisor(s): James, David (Professor)

The nutritional geometry of non-alcoholic fatty liver disease, cardio-metabolic health and lifespan

The global epidemic of obesity and type 2 diabetes (T2D) has been linked to increased consumption of ‘western diets’ containing an abundance of processed foods rich in s more...

Supervisor(s): Simpson, Stephen (Professor), Wali, Jibran (Dr)

Sorting proinsulin into secretory vesicles

Reduction in glucose-stimulated mature insulin secretion and increased constitutive and regulated secretion of proinsulin are characteristics of β-cell failure. This may be due more...

Supervisor(s): Kebede, Melkam (Dr)

The Gene Environment Interaction

-Interrogating how different diets interact with genetics in different inbred mouse strains -Examining the genetic and environmental influence on tissue specific metabolomics -Exam more...

Supervisor(s): James, David (Professor)

The primary cilia in diabetic kidney disease: targeting the cellular antennas

This project explores the role of the kidney proximal tubule cell primary cilia in diabetic nephropathy. Diabetic kidney disease is a leading cause of end stage kidney disease, requ more...

Supervisor(s): Panchapakesan, Usha (Associate Professor)

Effect of maternal high glycemic index diets on offspring metabolic phenotype

We are uncovering fascinating effects of different sugars (glucose, fructose, sucrose and isomaltulose) on development of embryos and offspring.  High glucose fed mice are sign more...

Supervisor(s): Bell-Anderson, Kim (Dr)

The autonomic consequences of sleep apnoea: A critical role for PACAP

We are interested to have Honours, Masters and PhD students join our team to investigate the role of PACAP and it's receptors in several models of sleep apnoea. We have exciting evi more...

Supervisor(s): Farnham, Melissa (Dr)

Harmful or beneficial aspects of oral facial tissue and environment to the cardiac regeneration: Periodontitis may worsen the outcome of cardiac function after injury whilst the orofacial stem cells may augment their regenerative capacity.

A rodent model of myocardial injury will be used to investigate cardiac function. We will investigate the detrimental effect of a chronic inflammatory disease (periodontitis) on car more...

Supervisor(s): Xaymardan, Munira (Dr), Eberhard, Joerg (Professor)