Taking proteomics to the clinic – biomarker and pathway analysis of patient samples
Summary
Only approximately 50% of patients will be successfully diagnosed by genetic analysis and even when a gene is identified, there may be no immediate drug target. Proteomics analysis of patient blood and fibroblasts can provide both diagnostic information and indicate protein pathways to target with drugs. The use of proteomics and phosphoproteomics is being developed as a rapid screening tool for personalised medicine
Supervisor(s)
Research Location
Westmead - Childrens Medical Research Institute
Program Type
PHD
Synopsis
Proteomics for rapid diagnostics and biomarker discovery in the age of personalised medicine.
Additional Information
The Synapse Proteomics group uses cutting edge proteomics and bioinformatics analysis to understand how protein pathways are perturbed in disease. Proteomics is used to determine disease-related biomarkers and protein pathways. We also study phosphorylation-based cellular signalling, since phospho-signalling is the earliest marker of pathways responding to environmental stimulus. Signalling is discovered using phosphoproteomics. The proteomics data is simplified using bioinformatics tools that are being continuously developed in collaboration. The screens may be followed by functional assays to verify new mechanisms that can potentially be exploited to develop therapeutics for diseases. Functional analyses may use genetic tools such as CRIPSR-Cas9, viral vectors or drugs in combination with a functional readout, such as microscopy.
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Keywords
phosphoproteomics, mass spectrometry, protein, molecular biology, post-translational modification, physiology, clinical, biomarker, Proteomics, Cell biology, Phosphorylation, Cell signalling, Personalised Medicine
Opportunity ID
The opportunity ID for this research opportunity is: 1008
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