Cystic fibrosis related diabetes

Summary

To determine if a low glycaemic index diet improves control in CFRD and/or slows the progression of impaired glucose tolerance to CFRD

Supervisor(s)

Professor Kate Steinbeck

Research Location

Westmead - Childrens Hospital at Westmead Clinical School

Program Type

Masters/PHD

Synopsis

Cystic fibrosis related diabetes (CFRD) is present in over 25% of older adolescents and adults with cystic fibrosis, and a similar number have impaired glucose tolerance (IGT). Continuous glucose monitoring (CGM) shows that the glucose metabolic abnormalities are significant, even in IGT. CFRD is associated with weight loss, deteriorating lung function and reduced life expectancy. CFRD significantly increases the therapeutic burden in patients who already have a heavy burden of self-management. The evidence based approaches to IGT in the general population, namely weight loss, exercise and metformin are not indicated in CF with its hyper-metabolic state and difficulty in maintaining a normal body weight. There are sound theoretical reasons why a low glycaemic index dietary intervention might be useful (see B Balzer, C Graham, M Craig, H Selvadurai, K Donaghue, J Brand-Miller, K Steinbeck Low glycaemic index dietary interventions in youth with cystic fibrosis: a systematic review and discussion of the clinical implications. Nutrients. 4(4):286-96, 2012), but empirical data are lacking and this project is an opportunity to undertake a novel and highly translational research project.

Additional Information

This is an opportunity particularly for a dietitian who is interested in an academic career to undertake an MPhil or PhD in an important and clinically relevant area. A sound knowledge of diet prescription is central to the study. Continuous glucose monitoring will also be employed in the project. There will be close links with Professor Jennie Brand-Miller and her team at the University of Sydney, and she and Professor Kate Steinbeck have collaborated on previous research projects

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Keywords

cystic fibrosis related diabetes (CFRD), impaired glucose tolerance, low glycaemic index diet, continuous glucose monitoring, Cystic fibrosis

Opportunity ID

The opportunity ID for this research opportunity is: 1173

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