Cancer Stem Cells

Summary

Cancer stem cell research

Supervisor(s)

Dr Lionel Hebbard

Research Location

Westmead - Westmead Institute for Medical Research

Program Type

PHD

Synopsis

We have developed primary liver tumour cell lines and wish to characterise the function of proteins involved in cancer stem cell function in tumorigenesis in vitro and in vivo. Such experiments will involve using lentiviruses to over-express of knock-down gene and corresponding protein function in these cell lines. We will then measure changes in signal transduction, cellular invasive function, apoptosis, proliferation and tumour formation in vitro and in vivo. We anticipate that the ablation of specific genes will perturb aggressive tumour formation.

Additional Information

Successful applicants will receive extensive training in mouse models, informatics, histology, biochemical techniques, signal transduction, tumour biology, isolating primary cells and stem cell assays. The completion of these projects will lead to a better understanding of the pathogenesis of liver cancer and fatty liver disease.

About the Storr Liver Unit
The Western Clinical School's Storr Liver Unit investigates the pathogenesis of liver disease, and the diverse causes of liver injury, such as drugs and toxins, metabolic factors and viruses. Internationally acclaimed, the Unit has made substantial contributions to defining how the liver responds to injury, and how genes involved in the metabolisms of drugs and toxic products of liver metabolism are regulated. Liver cancer is Australia's fastest growing cancer, and this is an opportunity to take a role in the research of this emerging health focus. The Unit is well funded and thus there is the opportunity to employed cutting edge techniques and tools to bring each project to fruition. Joining a successful research team with expertise in liver disease and cancer, there will also be opportunity to collaborate with internationally-renowned cancer researchers at the Westmead Millennium Institute. As part of the community of over 400 researchers based on the Westmead campus, there will be the possibility to utilise the Institute's state-of-the-art molecular, translational and cell biological facilities.

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Keywords

Cancer, Stem cells

Opportunity ID

The opportunity ID for this research opportunity is: 1184

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