Mouse models of Fatty Liver

Summary

The role of the metabolic syndrome in mouse models of fatty liver

Supervisor(s)

Dr Lionel Hebbard

Research Location

Westmead - Westmead Institute for Medical Research

Program Type

PHD

Synopsis

Overweight and obesity rates in Australia are now 60% of the population, and represent a national public health problem. Directly related to this is the increased incidence of diabetes, cardiovascular disease and cancer. Using knock-out mice fed cholesterol diets we now wish to analyse the affect of diet on metabolic differences, fatty liver and liver cancer formation. We find that certain lines of knock-out mice have more liver damage than normal mice. The successful applicant will examine for differences in lipolysis, inflammation, carbohydrate metabolism, systemic metabolism, undertake histology and biochemical analyses.

Additional Information

Successful applicants will receive extensive training in mouse models, informatics, histology, biochemical techniques, signal transduction, tumour biology, isolating primary cells and stem cell assays. The completion of these projects will lead to a better understanding of the pathogenesis of fatty liver disease.

About the Storr Liver Unit
The Western Clinical School's Storr Liver Unit investigates the pathogenesis of liver disease, and the diverse causes of liver injury, such as drugs and toxins, metabolic factors and viruses. Internationally acclaimed, the Unit has made substantial contributions to defining how the liver responds to injury, and how genes involved in the metabolisms of drugs and toxic products of liver metabolism are regulated. The Unit is well funded and thus there is the opportunity to employed cutting edge techniques and tools to bring each project to fruition. There will also be opportunity to collaborate with internationally-renowned researchers at the Westmead Millennium Institute. As part of the community of over 400 researchers based on the Westmead campus, there will be the possibility to utilise the Institute's state-of-the-art molecular, translational and cell biological facilities.

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Keywords

Liver disease, Fatty liver/steatosis

Opportunity ID

The opportunity ID for this research opportunity is: 1185

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