Combined, Correlative and Integrated Microscopy: Unraveling Biomolecular Structure-Function Activities in Cancer & Transendothelial Transport

Summary

Our team seek to understand the spatial and temporal mechanisms involved in the onset and progress of colorectal cancer by using state-of-the-art multidimensional microscopy and 3-D correlative imaging techniques. In this way, novel ultrastsructural information over micrometre-to-nanometre scales can be gathered to underpin the development and application of new targeted drug delivery strategies of for colorectal cancer.Other related work focuses on the development of 4-D simulation models of the colorectal tumour's in-vivo microenvironment in relevant organoid and animal models. In this work we explore the structure-function relationship of different subcellular compartments and molecules in various vascular models. 

Supervisor(s)

Associate Professor Filip Braet

Research Location

Australian Centre for Microscopy & Microanalysis (ACMM)

Program Type

N/A

Synopsis

This work will build on A/Prof. Braet's seminal work that cover the areas of structural biology, cancer biology, cell membrane biology, nanobiology, and chemical biology. 

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Keywords

Endothelium, Cancer, Nanobiology, Thearpeutic approaches, Fine structure immunocytochemistry, transmission electron tomography, correlative imaging, biomedical sciences, ultrastructure, histology, advanced imaging, endothelial biology and nanomedicine

Opportunity ID

The opportunity ID for this research opportunity is: 1502