Development of novel anti-cancer metastasis agents derived from omega-3 fatty acid metabolites

Summary

At present we have no therapies that prevent cancer spread. In this project we will develop novel w-3 fatty acid epoxide analogues that inhibit tumour metastasis. These derivatives will be developed as new anti-cancer agents by testing in cultured tumour cells and, later, in animal models. 

Supervisor(s)

Professor Michael Murray

Research Location

Camperdown - School of Medical Sciences

Program Type

Masters/PHD

Synopsis

Metastasis is the major life-threatening characteristic of malignant breast tumours; at present we have no effective therapies. Intake of w-3 polyunsaturated fatty acids decreases cancer spread, whereas w-6 polyunsaturated fatty acids, which are prevalent in western diets, stimulate tumour growth. We found recently that an epoxide of w-3 eicosapentaenoic acid inhibits the growth and spread of tumour cells. In this project we will extend this finding and develop novel w-3 epoxide analogues that retain anti-metastatic activity. The underlying hypothesis is such derivatives may be developed as novel anti-cancer agents with potent anti-metastatic properties. Techniques: synthetic organic chemistry using protocols developed in this laboratory. The molecules will be tested in cultured cells using a combination of real-time PCR and immunoblotting, cell migration assays and flow cytometry. Molecular modeling will be used to define the structural features in the molecules that are important for activity.

Keywords

Cancer, metastasis, tumour

Opportunity ID

The opportunity ID for this research opportunity is: 1547