Tubular autophagy in diabetic nephropathy
Summary
The central aim of the project is to define the role of autophagy dysfunction leading to renal tubulointerstitial fibrosis in diabetic nephropathy.
Supervisor(s)
Professor Carol Pollock, Dr Xin-Ming Chen
Research Location
North Shore - Kolling Institute of Medical Research
Program Type
Masters/PHD
Synopsis
Diabetic nephropathy is a devastating complication of diabetes mellitus and the leading cause of end-stage renal failure, accounting for 35-50% of all new cases requiring dialysis therapy throughout the world. Diabetic nephropathy is a multi-factorial process and we still have an incomplete understanding of its genesis and progression. Current treatments at best slow the renal functional decline. Hence further investigation into the pathogenesis of diabetic nephropathy, with the ultimate aim of developing novel therapies remains an area of active research. This project extends our laboratory's active pursuit of mechanisms and targets to reduce renal fibrosis with the aim being to mitigate the "tsunami" of renal failure predicted by epidemiologists and health economists. We have collective expertise in identifying the molecular mechanisms involved in the initiation and progression of diabetic nephropathy, with the ultimate aim being to develop new therapeutic strategies. The proposed studies will ultimately provide knowledge to target autophagy as a novel therapeutic target to halt the progression of diabetic nephropathy.
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Keywords
diabetes, Renal fibrosis, autophagy
Opportunity ID
The opportunity ID for this research opportunity is: 1733
Other opportunities with Professor Carol Pollock
- The role of miRNAs in diabetic renal interstitial fibrosis
- Predicting the future risk of chronic kidney disease in offspring of obese mothers with and without type 2 diabetes
- Novel therapy to prevent and treat kidney fibrosis
Other opportunities with Dr Xin-Ming Chen