Solute Carrier Transporters

Summary

PhD project is available in this laboratory on investigating the relationship of human drug transporters with drugs in treating prevalent diseases such as diabetes and cancers.

Supervisor(s)

Dr Fanfan Zhou

Research Location

Sydney Pharmacy School

Program Type

PHD

Synopsis

Human organic anion transporting polypeptides (OATPs) regulate the influx of drugs and toxins into cells. Natural polymorphisms and OATP dysregulation are important mechanisms by which drug uptake into cells is impaired, which influences efficacy and toxicity of therapies. We identified novel nonsynonymous single nucleotide polymorphisms (SNPs) in the specific OATP transporter gene in patients treated with anti-cancer agents. Expression and function of these transporter variants was decreased due to their dysregulation through specific kinases. The underlying HYPOTHESIS is that the specific kinases are novel regulators of transporter function. The OVERALL AIM of this project is to define the mechanisms by which these factors alter transporter function and expression in relation to drug uptake into cells. The SIGNIFICANCE of this study is that novel and important information will be obtained on the molecular regulation of OATP function and expression. This is essential for understanding the consequences of genetic variation in OATPs, which influences therapeutic outcomes.

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Keywords

solute carrier transporters, drug, toxicity, Polymorphisms, regulation, therapy

Opportunity ID

The opportunity ID for this research opportunity is: 1885