Immuno-metabolism of macrophages in inflammatory diseases
Summary
In metabolic organs like the liver and fat, macrophage infiltration plays a pivotal role in driving low-grade chronic inflammation that results in many of the consequences of obesity such as type 2 diabetes, heart and liver disease, and cancer. Our work suggests that alterations in macrophage metabolism are a key driver of the inflammatory state that ultimately contributes to the development of these diseases. This project investigates the link between glycolysis in macrophages and the glycolysis-dependent switch of macrophages to an inflammatory phenotype. Completion of this project will shed light on the metabolism of inflammatory cells as well as of cancer cells. The project will involve experiments on mice and in vitro studies on human monocyte derived macrophages.
Supervisor(s)
Research Location
Westmead - Westmead Institute for Medical Research
Program Type
N/A
Synopsis
It will be suitable for an Honors project or PhD studies.
Additional Information
Associate Supervisor - Dr Saeed ESMAILI
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Keywords
Opportunity ID
The opportunity ID for this research opportunity is: 1911
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