Pilot Study of Progressive Resistance Training for Sedentary Adults with Charcot-Marie-Tooth


This project is for a resistance training program in persons with Charcot-Marie-Tooth (CMT). CMT is the most frequently inherited peripheral neuropathy affecting around 1 in 2500 persons. CMT causes slow degeneration of the nerves in the extremities resulting in weakness including feet, legs, arms and hands. In the past, persons with CMT have been discouraged from performing exercise and physical activity because clinicians believed that such activity might hasten the disease; these beliefs have never been validated by studies or evidence. Evidence is required on exercise for persons with CMT, especially at moderate to high intensities. A considerable amount of weakness and muscle atrophy seen in persons with CMT is very likely due to secondary disuse due to inactivity. Exercise training might counteract some of the weakness and also provide persons with CMT "protection" from developing secondary metabolic disease or lead to improve functional ability in daily activities. The results of this pilot study will be promoted to educate persons with CMT and Clinicians on the benefits of exercise for CMT.


Dr Che Fornusek

Research Location

Exercise, Health and Performance Research Group

Program Type



The aim of this project is to investigate the safety and efficacy of power resistance training for individuals with Charcot-Marie-Tooth (CMT). We will investigate this with an 8 week training study. The study will provide data and allow calculation of effect sizes and subject numbers for a larger RCT that investigates power training in individuals with CMT. Our hypothesis is that power training is safe and efficacious for individuals with CMT. We expect power training to produce strength and muscle power gains to individuals with CMT. A secondary aim of this project is to investigate the relationship between muscle strength, muscle power, function and quality of life in persons with CMT.

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Resistance Training, Disability, Charcot Marie Tooth, Muscle Atrophy, exercise

Opportunity ID

The opportunity ID for this research opportunity is: 1932

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