Investigation on the causes for keratoconus

Summary

This project will be suitable for PhD students, and it can also be broken down to small projects for master students. It is basic science research based, and the student will experience and learn modern techniques in proteomics and genetics.

Supervisor(s)

Professor Gerard Sutton, Dr Jingjing You

Research Location

Camperdown - Central Clinical School - Save Sight Institute

Program Type

Masters/PHD

Synopsis

Keratoconus is a bilateral progressive, non-inflammatory degenerative ectasia of the cornea that causes loss of visual function, due to thinning and distortion of the cornea. It is the most common cause for a young patient to require corneal transplantation and occurs in up to 1 in 2000 in the community. At least 10,000 people are living with keratoconus in our country and around 400 new cases of keratoconus are diagnosed each year. It is the most common indication for corneal transplantation in Australia. The cause of the condition is unknown. We aim to examine the gene and protein expression on corneal tissues from both control and keratoconus patients using next generation sequencing and proteomics technique to determine the key regulating molecules for KC.

Additional Information

Please contact Dr Jingjing You on jing.you@sydney.edu.au for more information. Information regarding the research team can be found at: http://sydney.edu.au/medicine/eye/research/corneal-research/index.php

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Keywords

Cornea, keratoconus, Cell biology, Proteomics, Genetics

Opportunity ID

The opportunity ID for this research opportunity is: 2090

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