Interactions between Hepatitis Delta Virus (HDV) and Hepatitis B Virus (HBV)

Summary

Hepatitis B virus (HBV) is the leading cause of chronic hepatitis globally, but is also an oncogenic virus, with recent estimates that 53% of all cases of hepatocellular carcinoma (HCC) in the world are HBV-induced. Co-infection or super-infection with hepatitis delta virus (HDV) is believed to cause more severe pathology, worse liver damage and increase the potential for cirrhosis and HCC. The balance between HBV and HDV replication is critical for the outcome of co-infection, as both viruses share the same envelope, which contains the hepatitis B surface antigen. Typically HDV suppresses HBV replication and virus production, but this is variable and the mechanisms involved are not well understood.

Supervisor(s)

Associate Professor Mark W Douglas

Research Location

Westmead - Westmead Institute for Medical Research

Program Type

Masters/PHD

Synopsis

Currently positions are available for the following research projects:
1- Quantitatively analyse the HBV-HDV homeostasis in co-infected cells, where both viruses share common cell machinery
2- Compare HDV co-infection and super-infection, to determine the relative inhibitory effects of HDV on HBV virus replication, and vice-versa, to better understand the mechanisms involved.
3- Study co-infection and super-infection with HDV with respect to different HBV genotypes, as well as the effect of mutations in the HBV X-gene, in the basal core promoter (BCP) region.
4- The effect of interference between HBV and HDV on liver pathogenesis, leading to HCC.

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Keywords

Hepatitis D, viral hepatitis, hepatitis, hepatitis B, Virology

Opportunity ID

The opportunity ID for this research opportunity is: 2134

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