HUMAN MINIBRAINS GROWN FROM STEM CELLS

Summary

This project will involve CRISPR genome editing strategies combined with human stem cell derived mini-brains to investigate new neuronal factors that control development, cognitive function, or neurodegeneration.

Supervisor(s)

Associate Professor Greg Neely

Research Location

Charles Perkins Centre - Greg Neely Lab

Program Type

PHD

Synopsis

It is now possible to grow human min-brains in tissue culture. When coupled with revolutionary new CRISPR genome editing systems, we are now well positioned to understand the basic genomic logic that controls human brain development and function. This project will involve functional testing of new whole genome sequencing data using CRISPR-based manipulation of human mini-brains. The successful candidate will be trained in advances molecular biology including CRISPR-based genome editing, how to grow and functionally test brains and other organoids from human stem cells, as well as live calcium imaging, electrophysiology, 2 photon microscopy, etc. as the project requires. Exceptional applicants may qualify for an additional elite top-up scholarship worth up to $10000 per year.

Additional Information

HDR Inherent Requirements

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

- Confidential disclosure and registration of a disability that may hinder your performance in your degree;
- Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
- Ability to perform independently and/or with minimal supervision;
- Ability to undertake certain physical tasks (e.g. heavy lifting);
- Ability to undertake observatory, sensory and communication tasks;
- Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
- Ability to work in confined spaces or at heights;
- Ability to operate heavy machinery (e.g. farming equipment);
- Hold or acquire an Australian driver’s licence;
- Hold a current scuba diving license;
- Hold a current Working with Children Check;
- Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

CRISPR, Genome editing, human stem cells, Neuroscience, Neurodegeneration, Biochemistry

Opportunity ID

The opportunity ID for this research opportunity is: 2197

Other opportunities with Associate Professor Greg Neely