Muscle wasting and vitamin D

Summary

Muscle wasting and weakness are common, and associate with an increased risk of death. Therapies to improve muscle function are very limited, and understanding of the transcriptional control for myocyte development and function is limited.

This project will work with transcription factor vitamin D receptor and its role in myocyte and satellite cell (muscle stem cell) development.

Supervisor(s)

Professor Jenny Gunton

Research Location

Westmead - Westmead Institute for Medical Research

Program Type

PHD

Synopsis

This project will involve opportunities to work with novel genetically modified mice, TRAP (translating ribosome affinity purification), RNA-sequencing, histology, muscle fibre typing and some human samples to study the role of vitamin D, its analogues and the vitamin D receptor in muscle function.

Additional Information

Westmead Institute for Medical Research has a ‘top-up' award program for students who are successful in obtaining a scholarship (e.g. Research Training Award).

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Keywords

muscle, myocyte, myopathy, sarcopaenia, sarcopenia, weakness, satellite cells, Vitamin D, Vitamin D Receptor, Transcription factors, RNA-sequencing, translating ribosome affinity purification

Opportunity ID

The opportunity ID for this research opportunity is: 2248

Other opportunities with Professor Jenny Gunton