Melatonin Supplementation for Cognitive Decline


This study is investigating the effects of Melatonin supplementation on brain oxidative stress, sleep and vascular function in people living with Mild Cognitive Impairment. Other aspects that could be incorporated could be the role of disrupted sleep, the body clock and/or sleep disorders in cognitive decline.

The supervisory team also inlcudes Dr Shantel Duffy.


Dr Camilla Hoyos, Associate Professor Sharon Naismith

Research Location

School of Psychology

Program Type



With the rapidly ageing population, diseases that affect the brain including dementia are increasing. A large body of research now demonstrates that there are some 'modifiable' risk factors of cognitive decline. It is now a focus of research to understand whether early intervention programs targeting these risk factors are effective at altering important pathways associated with cognitive decline and the development of dementia. This project incorporates a pilot randomised clinical trial of melatonin supplementation in participants with mild cognitive impairment (who are known to have an increased risk of dementia). Outcomes include several modifiable risk factors including underlying brain changes (measured using a MRI scan), sleep, mood and vascular health.

Additional Information

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

  • Confidential disclosure and registration of a disability that may hinder your performance in your degree; 
  • Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo); 
  • Ability to perform independently and/or with minimal supervision;
  • Ability to undertake certain physical tasks (e.g. heavy lifting);
  • Ability to undertake observatory, sensory and communication tasks;
  • Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
  • Ability to work in confined spaces or at heights;
  • Ability to operate heavy machinery (e.g. farming equipment);
  • Hold or acquire an Australian driver’s licence;
  • Hold a current scuba diving license;
  • Hold a current Working with Children Check;
  • Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)
You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.
The supervisory team also includes Dr Shantel Duffy.

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Sleep, dementia, mild cognitive impairment, Intervention, prevention, clinical trial, melatonin

Opportunity ID

The opportunity ID for this research opportunity is: 2362

Other opportunities with Associate Professor Sharon Naismith